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Yes you can activate them using the numbers above qwer like B-Wong said. They are in order of your items. For example, you activate the item in the first spot of your items by pressing one. I find it best to move the active item to the spot you find easiest to activate.
Haikus are easy
But sometimes they don't make sense
Refrigerator
But sometimes they don't make sense
Refrigerator
If you can make one, how to do so? I would probably get Active Items more if I didn't feel gimped trying to get to them mid-fight.