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No, it's whichever one is better against champions, it's always flat+ap vs minions.
ReprobateReality, you seem to be giving me a generic response to getting Bloodrazor. Did you not see I end with 10% + 64 magic pen? The magic pen really adds up. Your ult stacks malady and hit's bloodrazor; even WW's passive does magic damage per attack. When you ult someone in combo with your Abysall, they will have 44 MR reduced for your AP to follow up on if he/she even needs to. Also the AP isn't wasted as the damage is percentage HP PLUS 1 to 1 AP ratio. I also explained I have gotten Gunblade and Wota before for 700 HP Q's, but it is worthless without resistances if I get burst anyway. The main build balances damage and resistances, and I even said get Wit's End or get an early Negatron if you really need the MR. Please actually read the guide instead of just copy pasting, thanks.
Dude learn to take criticism, it's ok to disagree and retort with your own argument but don't get pissed off. You really need to learn BB coding; it will make me actually want to read your guide lol
Malady is a nice item, but Wit's End is better because it gives magic resist. You'll still have attack speed. Also, AP is wasted on Warwick as Hungering Strike strikes for percentage of enemy's health, which can only be overcome (doing more damage) by going full on AP carry. Magewick died long ago.
Overall, a great start. Keep it up :D you can also learn how to make a guide from jhoijhoi's making a guide - http://www.mobafire.com/league-of-legends/build/making-a-guide-101506. It'll help with the guide's image so it'll look more appealing.