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In lane and in late, this is quite a hard matchup due to his sustain and high damages.
If you want to fight him, you have to burst him. If you fail, run away. Be careful of his passive in lane.
Ahri
Ahri is quite easy to kill, just be surprising and avoid her kiss.
Akali
Wait what? You must be in normal if you are against another Akali.
That mirror matchup is based on skill and on your way to play Akali. You have to burst her before she does, use your Twilight Shroud after she uses her.
Amumu
Amumu is generally tanky and has high crowd control abilities - plus, he has damages. You will have to poke him (Q + AA) and escape many times to kill him. Avoid him.
Anivia
Anivia is bursty but you can easily get rid of her. Just avoid to be killed before you kill her.
Annie
Annie is very difficult to kill while her passive is up. You can slay her when she has used it and when Tibbers is on cooldown.
Ashe
Ashe is an ADC. ADCs can't live when you're Akali.
If she's fed though, flash or ult her ult, otherwise you'll be killed.
Aurelion Sol
He is quite disturbing in lane. Avoid his passive in going close to him. After your level 6, he is a free target.
Azir
All depends of how he is playing. You can't dash through his wall, so be careful to his burst. The laning phase is quite hard since he can poke when his thunderlord is up. In mid or late, he is very sensitive to your burst.
Blitzcrank
One grab and you die. Flash or ult his Q and avoid being close to him. Crowd control his the cancer of Akali.
Brand
He has poke and crowd control, so you'll have to burst him before he burst you.
Caitlyn
Caitlyn is an ADC. Like any other, avoid her CC (E/W) and execute her.
Cassiopeia
Avoid her ultimate and everything must be ok. She has a lot of damages though, so be careful to be unseen before going on her.
Cho'Gath
High damages, crowd control. Avoid him like Amumu.
Corki
Nothing to say. He is an AD carry. Just kill him.
Darius
As Amumu or Cho'Gath. Avoid him.
Diana
Diana has crowd control and a huge burst. Mostly of the time, she also have a Zhonya. Fight her when her E or her Q is down. Even better if her Zhonya is down too.
Dr. Mundo
Worse than Darius or Cho'Gath, that thing is gonna chase you down and regenerate like crazy. Avoid him.
Draven
He is an ADC but he has more damages than the over - and his bump can kill you if he is fed. Be careful.
Ekko
Avoid his stun. You must kill him when he does not expect you - otherwise he can R or E + Q to kill you.
Elise
Elise is very burstly and quite tanky. Be careful trading her, you may kill her if she is low-life. Otherwise do not go on her.
Evelynn
Be careful of Evelynn, she can come from anywhere and kill you when you do not expect her. Use your Red Trinket or Control Ward.
Ezreal
AD carry. Kill him.
Fiddlesticks
His fear and lifesteal can be a threat. Kill him when those are on cooldown.
Fiora
Fiora has lifesteal and mobility. And damages. Avoid her.
Fizz
Try to kill him when his E is on cooldown. Avoid his ultimate with your flash or ultimate.
Galio
Galio is a quite weird champ. His shield is a threat to you and he can burst you with his ultimate. Fight him with your team (no, let's say that your team must be fighting him before you come from behind to kill secure).
Gangplank
You have to avoid his barrels with your flash or ultimate to kill him. If you can avoid flashing because of his barrels, do it for his ultimate if you're low-life at the end of the fight.
Garen
In early you can poke him easily, but in late you have to avoid him.
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