Miss Fortune Build
Not Updated For Current Season
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
I will try to pretty this up when I learn how.
This build functions well through all stages of a match.
Because you will not be using Manamune, early mana conservation is important. Only use abilities on enemy champions, not minions. Your main harass will be your autoshot. There's nothing quite like a crit on the first shot taking down a third of a champion's health.
The stacks from Impure Shot are not to be underestimated. Take full advantage of the fools that sit there hacking away at minions while you stack damage on them.
Because Miss Fortune is so squishy, you must always have a way to escape. This is where ghost and flash come in. Flash through walls and Ghost through minion swarms to gtfo when you're faced with multiple opponents alone.
Later on, your crit chance will increase to 55%. This gives you awesome damage potential, and straight AD from your Infinity Edge, Bloodthirster, and Black Cleaver will also effect Bullet Time, allowing you to quickly bring enemies (even tanks) down fast.
Use the synergy of active Impure Shots and active Youmuu's Ghostblade to devastating effect. When both are activated, you will have doubled your attack speed instantly and cut their healing in half. Combined with the amount of pure damage you are putting out, any and all champs will drop like flies.
Be judicious about which enemy champions are around when starting an attack. Blinds will be the death of you, so it's usually better to avoid champs like Teemo or Heimer unless they are already preoccupied by your (in a perfect world) wonderful teammates. Remember that any ability that stuns, knocks in the air, or silences, will kill Bullet Time. Awareness is a must.
Remember your synergies. Impure Shots passive + Black Cleaver, and Impure Shot active + Youmuu's Ghostblade. Guaranteed kill if he's busy attacking a teammate.