Not Updated For Current Season
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
Akali... Who is Akali ?
She is '' mele mage '', I know it sounds bad but it's true.
So Akali will need AP, NOT AD.
Akali has very iteresting passive skill.
I always tell - ''Akali has TWO passive skills'' You can tell for it what you want.
For activate ''1st passive'' at 1 level you'll need 10AD (~8AD with runes, ~2AD with tallents = 10AD at start) - this is ''AD PASSIVE''
''2nd passive'' need AP, so at start I always buy Amplifying Tome and I have this passive, btw I have activate full akali passive skill at 1 level. - ''AP PASSIVE''
You need 30lv to get ''2 passive skills at 1 level'' with this build !!!
You'll need ONE AD mark, rest standart Magic Penetration.
I'll always use Armor runes, coz Akali doesn't need much dodge, but need something for defense. Akali can easly get multikill and fight 1 v x so Armor runes is enough.
Ap/lv runes is the best way to get more AP on Akali.
Flat AD runes is needed to get 10AP at start (+ one mark for AD) and activate first passive skill (without items).