Not Updated For Current Season
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
This build focuses heavy on attack speed. It has a little bit of damage, but it mostly focuses on attack speed because of how strong Silver Bolts and Madred's Bloodrazor combine. Also, this build is meant for mid, and I would strongly recommend you take the middle lane with mid. She gets heavily focused in a side lane, but she is a great 1v1, making her a good mid. She is also a great ganker. That being said, Vayne still can do a good in a side lane, but ONLY if she has a tank. She needs somebody to keep the attacks off of her. If you don't have a tank, you will be heavily focused and die fast.
[*] Berserker Greaves [*] Sword of the Divine [*] Madred's Bloodrazor [*] Starks Fervor [*] Frozen Mallet [*] The Black Cleaver
In the even you finish your build, drop the [*] Sword of the Divine. It is good attack speed but its passive doesn't do much damage late game, so pick up [*] Phantom Dancer.
[*] Beserker Greaves
This is a good attack speed boots and I believe is the best. If you play a ganky Vayne though, you might want to switch these out with [*] Boots of Mobility
[*] Sword of the Divine
Great passive that stacks with Silver Bolts. Can be switched with [*] Wit's End if you want, but this item can be sold late game since it won't do as much damage anymore. REMEMBER TO USE THE ACTIVE.
[*] Madred's Bloodrazor
This is an expensive item, but it's passive stacks AMAZING with Silver Bolts. In 3 shots, you've taken out AT LEAST 20% of their health.
[*] Starks Fervor
Nice little boost of lifesteal, and nice attack speed. If you feel you want a little more damage instead of attack speed, it can be switched with [*] The Blood Thirster
[*] Frozen Mallet
Later game, Vayne can really use a little health boost. Frozen Mallet accomplishes this and slows them when she attacks them, which is also nice.
[*] The Black Cleaver
Great damage, more attack speed, and passive really helps destroy Champions.
[*] Phantom Dancer
I recommend this if you finish your build, than it can be switched out with Sword of the Divine.