General Guide by
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Well,sorry for my english mistakes,but here I go,
Brand is my fav mid champ I have 2433 elo atm EUW,playing with him a lot of ranked games ( 25 win 2 lost season3 yet).
So let's start with this guide right now.
Basically i use for brand 2 brand rune pages: 1. 8 magic pen(red),at 18lvl 25ap(blue),armor +13 (yellow),14.5 ap (purple runes). Or,if u think u win mid easily and u thinking about roming a lot u should take same runes just purple runes not ap but movement speed.
Masteries is simply 21/0/9 , if ur smart u no need mana regen or mana, so go 21 offensivelly for some dmg output at the beginning and late game, and 9defensive for hp per level, armor,manig resist.
so ur brand items depends on enemy and ur team champs: but basically u always start with boots and 3,4 pots,then rush couple doran's. then rush liandrys torment and finish magic pen boots,after go for deathcap,and then its all depends on u , well normally i go for ga or rylais for sustain in team fights,then for magic pen or abyssal and finishing with zhonyas.
So its easy if u wanna go aggresive (i do so) u will start with Q then max E , ur skill setup should be like this : lvl 1 Q , lvl 2 E,lvl 3 E,lvl 4 W, And then max E and Q (ofc dont forgoet ulti 6,11,18 :D). So what u have to do,just poke enemy with q + basic attacks and so on,when times right just e+w+q+r+ignite+flash if needed and its dont ur unstopable. really it is all depends how u can play and farm on lane.
Dont forget it if ur like 7/0/0 dont think ur god. cuz ur greedy play can just threw whole game. suggest rome lanes and help others. buy more wards for the team. :)
what i can say. as to me i can beat any mid champ with brand but if mid goes bruiser like talon and zed its ****y ( ofc it depends how talon or zed plays) :)
well u have to take good position for harrasing enemy team and when it times come w+e+r+q or something like that and poke nonstop ofc dont be greedy dont die like ****t. be smart. think of all enemy champs abilities.. :)
unique skills that if ur team like 3/20 in ranked u can easily carry them. just rome,win ur lane and u will see :)