Brand is a pretty squishy champion which is able to give you tons of dmg with 1 combo. It wont be easy to play him with this build. Rylai's scepter is the ONLY item which will give u some survivability.
I accept any criticism, I am willing to improve this guide according to ur feedback.

Kthxbai!

Pros:
Ridiculous amount of dmg in early/mid and late game
Great Farmer
Is able to stay behind ur team and get kills!
AOE DMG


Cons:
VERY SQUISHY
CC's will rape you :(
Need kills in early game to make a lot of dmg in ur end game

Runes are very important for Brands early and late game!

1. Greater Mark of Magic Penetration
I took this Mark for lot of magic penetration in early game. It would be great for ur mid game to get first blood.

2. Greater Seal of Replenishment
Brand has a lot of Mana problems in his early game and its not expenive :D (u will fix this problem with Blue buff / Archangels staff)

3. Greater Glyph of Cooldown Reduction
I experienced that Brand has long cd times. U will need CD reduction very often because im not sure if u want to use auto-attack in a 1 on 1.

4. Greater Quintessence of Ability Power
Pwnig teh nubz to get first blood... nuff said.

Weeeeelllll, u can take the 9/21/0 way or the 9/0/21 way.
I think that the second one is better cuz u need speed + CDR and Mana regen.
The first one is pretty nice too (more ap & def) but u need CDR!!

Its actually ur choice, everyone has his own style of playing Brand.

1. Sorcerer's Shoes
Uh.. Magic penetration is important for ur dmg. ;P

2. Mejai's Soulstealer / Morello's Evil Tome
Its ur choice again!
Take Morello's Tome if ur early game sucks.
Take Mejai's Soulstealer if u get first blood or even 2 kills! ^_^

3. Archangel's Staff
VERY IMPORTANT ITEM!!!
It will fix ur Mana problem + u will get lot of mana + AP!!
Do not skip this item!

4. Rylai's Crystal Scepter
Hp + Ap = nice
Hp + Ap + Slow = even better!

5. Rabadon's Deathcap
Huge amount of Ap which is enough to kill almost EVERY squishy champion with ~1 combo

6. Void Staff
I took Void Staff cuz of my Runes, Masteries and Sorcerer's Shoes
49% Magic Penetration (Masterie and Void Staff) + 29 Magic penetration (Runes and Shoes) !!!

thx to Infamousneer
6.1 Frozen Heart
Great item if u think that u are to squishy, it will help you to survive some 2 vs 1 situations and u have a lot of CDR either!

1. Ghost
Brand doesn't really have a escape mechanism (okay his stun but he wont help u in a 2 vs 1)
U will be able to Escape with Ghost and u will be able to Chase with Ghost!

2. Ignite
His Passive is pretty good to harass ur enemy's but 2 dots are always better then 1
Ignite will help u to kill a enemy with low hp and enemys like Vladimir. 50% less healing is a perfect weapon against him!

Brand's spells light his targets ablaze, dealing 2% of their maximum Health in magic damage per second for 4 seconds.




This passive skill is Awesome!!
U won't have any problems with harassing ur enemys!
Huge amount of dmg on enemys with a Huge amount of HP :D



Brand launches a ball of fire forward that deals magic damage. If the target is ablaze, Sear will stun the target for 2 seconds.



Don't use this skill to Harass ur enemys!
Use it to STUN ur enemy.
Yes, to STUN!!
Its not easy to aim with this skill but after some tries u will hit almost every time.
Stun your enemy and use Pillar of Flame. Great in a 1 vs 1!



After a short delay, Brand creates a pillar of flame at a target area, dealing magic damage to enemy units with the area. Units that are ablaze take an additional 25% damage.




AOE dmg is very important!
And its Pretty cool cuz u will get a lot of assists (or kills) in teamfights!

1 vs 1:
Conflagration => Sear => Pillar of Flame => (maybe Ignite) => ??? => Profit!

Team Fight:
Pillar of Flame => Pyroclasm => Conflagration => Random Sear => Ignite on the enemy with lowest HP => ??? => Profit!




Brand conjures a powerful blast at his target, dealing magic damage to them. If the target is ablaze, Conflagration spreads to nearby enemies.



Another ~AOE~ Skill!
Use it to kill minions ( Pillar of Flame => Conflagration )

Use it in teamfights!

Use it in a 1 vs 1 so your enemy will get ur passive in his face!


Brand unleashes a devastating torrent of fire, dealiing magic damage each time it bounces. If a target is ablaze, Pyroclasm's missile speed increases.


Brands Ulti is Great in Teamfights or 1 vs 2!!
Use it on maybe Teemo and Master Yi so it will bounce between them!
Then try to hit with Sear so u can stun 1 of them...

Another Possibility is to use it on enemys with low hp (they will probably run away)
Use ur Ultimate so it will bounce and kill them ^___^

If u think that this guide sucks u are doin something wrong
if u think that this guide rocks! then u've right