Not Updated For Current Season
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
Brand is a rather straight forward mid champ. His cast animation for his auto-attack is quick so last hitting is a breeze. Focus on last hitting and only harass your opponent if an opportunity presents itself. If your opponent is a bit skiddish then playing agressive can't hurt all that much but essentially you'll focus on denying your opponent vs killing them outright.
Early game you simply rely on auto attacks to last hit creeps saving your spells for the enemy champ. Conflag will be your primary harass, once you get Pillar of Flame however it (your now 2-button spell combo) becomes a very effective deterrent to your enemy.
You should lead with flame pillar however hitting your enemy with conflag before flame pillar pops. This means your opponent gets the bonus 25% damage from being ablaze. It takes some practice to lead your opponent or predict their movement. Most players tend to retreat when an enemy presses forward, use this to your advantage. Lay your Pillar of Flame behind you enemy if in range. They'll walk right into it (hopefully).
By level 5 you have Sear and his is where the fun begins. If there aren't any creeps in between your opponent and you then you can probably score a kill. Lead with Conflag then Sear and then flame pillar. If you had proper timing and hit you enemy with Sear, stunning them you just nuked ~75% of their HP (If they weren't low enough already) this is where Ignite comes in (if you took the summoner spell) Sear should come off cool down just in time for you to throw another attack at you opponent hopefully finishing them. Often enough it is Brand's passive Ablaze which does the last few points of damage to a target.
Mid Game by level 9-12 you should obtain your Rylai's Crystal Scepter or Rod of Ages. Rylai's give you a nice chase mechanic because every one of your spells now has a slow attached to it. Team-fights start breaking out you simply sit on the fringe and nuke an opposing team's carry. Save your ultimate for the end of the team-fight. OR as you see opponent's retreating.
Late Game-Stick to your team like glue, never be the first one in to a fight be sure to be the first one out if possible. Brand can clear creeps well but pushing is not one of his stronger traits. You should let your team mates push and simply back them up.If someone else takes mid don't worry. Brand has some great lane abilities too. You can synergize well with another ranged champ like Teemo, Lux, Sona,Morgana anyone with a solid CC/disable. Teemo's blinding dart, Lux's slow or snare, Morgana's Snare.
But Brand also works well with some melee champs too. Blitz, Shen, Rammus, Nocturne, Sion. These champs have a solid CC between stuns, snares, fear, and taunts as well which will allow you as Brand a better chance at using combos. Blitz Rocket grab, knock up into Conflag+Sear+Pillar of Flame. Sions stun into Conflag+Sear+Pillar of Flame. The lane comps go on it just depends on how good at coordinating attacks you are.
Your primary focus in the lane is to help deny your opponents. As a ranged nuke you have some superb harass at your disposal. With the right lane partner you can almost completely deny your opponent's ability to earn gold which puts them at a defecit early on. Focus on last hitting with auto attacks and be sure to zone your opponent properly. Play heads up though and be aware your enemies may call for help to gank your lane at some point.
These mastersies give you a better defense, the Brand is very weak in the beginning, with this mastersies you will have a stronger structure for the line or midding .... at the end of a combination of items and mastersies you will have a strong defense and endurance!
These items give you a high HP and high MP in combination with solid MR. You do not need a lot of AP to create great damage but will need a high HP as well as a solid MR!
Greater Mark of Alacrity will give you much needed speed of the attack, for farm and for harrasing enemy, Greater Seal of potency-Greater Glyph of potency-Greater Quintessence of potency will give you a strong start and enough AP for harrasing or killing the enemy!