Not Updated For Current Season
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
1. early game.
In early game brand must attack range, dealing lot of damage, and dealing damage over minions. The best idea is Pillar Of Flame. If you bought mana regen, you can spam with Pillar Of Flame dealing a lot of damage. If enemy is coming to you, you put this ability between you and enemy and hit him.
Every skill used on your target you burnd it. If your target is burned you have bonuses in your skills. So that combo is: beginning conflagration burning target. ther sear with bonus stun. stun is long, so you can use pillar of flame with bonus damage. then ignite or ultimate, and nice kill :D