When you die early
If they got much cc
If you had to go Qss build it for Lifesteal
Not Updated For Current Season
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
Threats to Vayne with this build
|Ezreal||Skillmatchup, don't get hard poked in early and stay behind minions if you want to trade with him|
|Lucian||He is much stronger then you in early, but you can still outplay him after lvl 6|