This will be xKINGxxDx's guide to Darius, The hand of Noxus. I will discuss the runes, Masteries, Items, Skill Sequence and pros/cons of my build.

The Runes I use to play most of my fighter characters are the same usually. I mostly and trully only use Attack speed runes for the red, yellow, and blue. The purple are Life Steal runes. Hit fast and your HP will never go down no matter how much the enemy hits you.

The Masteries I use again reflect the Runes I use. I go with Attack DMG, Attack Speed and Life Steal, and I throw in there some other things if I have the ones I want maxed out. I then go on the Defence.
Which is 21,8,1 with the 1 being Improved Recall so I can get back to base faster get my items and heal and be back so my ally can do the same.

The items I try to obtain while I play Darius reflect on both my Runes and Masteries as-well as Darius' passive ability to penetrate Armor. I start off with the "Boots of Speed" and "Dagger" working my way to "Berserkers Greaves". Next I like to work on getting "The Bloodthurster" by starting with "Long Sword" upgrading to the "Vamparic Speter" and then getting the "B. F. Sword".
Next I will get 2x "Long Sword" upgrading to "The Brutalizer" then the "Ruby Crystal" to make "The Black Cleaver". Next Item to get would be the "Frozen Mallet" because you need that movement speed reduction if you are ever to catch anyone you can get the items in any order for this item.
The Next item I get its for attack and movement speed its the "Phantom Dancer" I like to start off with getting "Zeal" first then the "Dagger" then the "Cloak of Agility". Last item I get is the "Last Whisper" because with all this Armor pen. its worth it. Some time I might upgrade to the "Boots of Swiftness" if I am ahead of my allies in gear so I can go help them push a lane fast.

Ok I'm gonna make this a little easy(er) D=Decimate, CS=Crippling Strikes, A=Apprehend, NG= Noxian Guillotine. Now to start off I always go bottom lane so I like having Lets say Darius' Brother DRAVEN at my side coming with me to bottom. The ability I like to start off with "IF" I have a ranged ally going with me is Decimate, but if I have another melee ally with me I go with Crippling Strikes.
Now the Sequence I level my abilitys up depends on what I just said but it only affects the first 2 in my Sequence.
If melee ally: CS,A,D,CS,A,NG, and so on depending on what your fighting if your fighting two ranged go with A and CS maxed first.
If Ranged Ally: D,CS,A,D,CS,NG and again so on depending on what your fighting and if your ally aint a noob. lol JK

I like to use Heal and Smite as my Summoner Spells. Heal so I can not only stay in the lane longer but I can also keep my ally in the lane longer as well. I use smite because I farm the lane not alot of people do this but I do, I also use it to push the lane by eliminating one of the enemys minions before they even get to attack.

The Pros about this build is that you can HIT HARD, HIT FAST, AND REGENERATE YOUR HP FAST.
The Cons how ever are you MIGHT have low hp and defense in some peoples eyes but I say the life steal makes up for it.