Not Updated For Current Season
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
Pros / Cons
One of the top gankers
Open to stuns
countered with wards and oracle
Not an initiator
Twitch isn't a great farmer unless you want to waste your ultimate on a wave of minions so its best you follow this. The absolute best way to farm gold with twitch is to be very aware of your surroundings and scout a lot, help gank any time its possible but dont over extend, you are not an initiator so let your teamates begin the fight then pop out for the desolation of the enemy team.
Creeping / Jungling
Generally you wont be jungling much as twitch as he is a all around ganking character but mid-late game twitch does have the ability to get dragon or any of the jungle creeps on his own with no problem.
Team work is the absolute most critical thing needed to do anything with twitch. i could never stress this enough. Sure twitch may be able to open up a fight and kill one person sometimes but through teamwork using twitches abilities to destroy the enemy team is when he shines.