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Elise is a champion that has a skillset like no other. This means that you can adapt to a variety of situations and oponents. Not an easy champion but extremely powerfull.
For Elise to have a good and versatile build we need Armor/MR along with some extra HP and SpellVamp for high sustain and to survive ganks.
On my elise build i like to build MR/level and Armor per level for defense. For offense, Marks of MP/AP. Quintessnes of Spellvamp for a bit more of sustain as this guide for Elise is desiged for top lane.
This takes care of our defensive stats. For Elise to be a good bruiser we need to meka her have good CDR and AP. This champion scales well with both of them. For CDR we have Nashors Tooth plus 6% from masteries (this is suficient).
For AP, every item on this build has AP and the total AP will be close to 500.
500 AP means your Q will deal 8% + 15% of targets current/missing health.
With the CDR from this build Q can be spamed every 3.6 seconds.
500 AP also means spiderlings deal 100 damage.
Mid to lategame eficiency for Armor and Magic Resist. Some spellvamp for sustain as Elise needs to sustain in Human form and keep high health before changing to spider form for melee attacks.
Greater Mark of Hybrid Penetration
Greater Seal of Scaling Armor
Greater Glyph of Scaling Magic Resist
Greater Quintessence of Spell Vamp
These masteries are chosen for sustaining, CDR, movement speed and extra early items (Ward and biscuit).
Mid game build:
This is the final build of Elise.
Pros / Cons
Highly versatile and adaptable
Damage as % of Health
Can zone out most champs with Q and W
Can be untargetable
Tanky in spider mode
W in Human form can scout nicely while E in spider form can scout and evade
Tower killer :)
Can take out objectives like Baron and Drake alone
Hard early start
Dificult to master
Skill sequence is highly dependable on your situation.
First three levels are used for the three base skills. E will be the last one to max but it is very important to get it early to escape ganks or to gank other lanes.
Q or W will be your choice dependind on how you can harass better and the opposing champion.
I use Q to maintain enemy champ at a relatively low HP and then try to zone him out with W.
My main spells for Elise top are Flash(or Exaust) and Teleport.
Flash is nice for escaping or chasing as well as Exaust.
Teleport allows you to gank often and come back to your tower faster. This is very important in the first levels as Elise is not very tanky early game. First Teleport will most likely be used for fast shopping and return to lane.