Not Updated For Current Season
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
With these two champions in a lane is like instant win. Purchase all items in order. Sell Garen's Doran Shield when you get the bloodthrister. At the start of the game Singed will fling the target backward and poison them and Garen will silence the champion but not killing him or her. After he/she comes back Singed will poison the target and garen will dive for the kill