Veigar Build Guide by yodisho
Not Updated For Current Season
Veigar - Late game Destroyer
Not Updated For Current Season
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
Quick Strategy Explanation
This build is for a late game Veigar. Requires farming your Q, but leads to deadliest single target AP attacks.
Early game- spend as much time in the lane as you can (should be able to last until at least level 5 before recall). Farm your Q as much as possible, don't use it to harass other champ. Since you will get your stun at level 2, you can use that only for your protection or if your team jungler comes for gank. If anyone chases you to turrets (which should not happen), you can use your stun to surround them and make sure the turret hits them at least 3 times. At about level 5, recall and buy the first back items(full boots if you can) then teleport back to midlane. You should only be gone for about 6 seconds. Keep up the farming of Baleful Strike.
Mid game - At this point you should be able to take out groups of minions with Dark Matter. You can keep farming and building your Q, while unloading your combo at any near by champs or in team fights. You can also do some damaging hit and runs by stunning then using your dark matter.
Late game - This is what you have been waiting for. Simple enough, stay behind a teammate and unload your combo into a single champ to kill him (even tanks). Land your Event horizon first, then use Dark Matter on the edge where the champ should be stunned, then use Deathfire Grasp, then use Baleful Strike, and finally use your Ultimate. After this combo, the champ will definitely be dead. *if the champ is not strong or does not have full health do not use your ultimate on him for no reason*.
Side notes - *Practice landing Event Horizon directly on your opponent. Some enemies are smart enough to stay inside the circle and attack you. This will allow you to stun him right away and usually other champs do not come close allowing you to nuke the champ you caught.
*If you practice enough, you can cast Dark Matter first then Event Horizon and still land your combo. If you can do this, you can postpone the level 7 upgrade in Event Horizon to level 17 and upgrade the rest of the abilities one level earlier.
* Make sure you use Event Horizon as best as possible in the situation. You can use it to help you or a teammate escape, use it in a team fight to stun multiple champs, land it directly on enemies, or land the edge on yourself to stun enemies who can jump to you.
*Do not go into brushes that you think enemy champs are, you can use Dark Matter in the brush to see, since the ability allows sight where it lands.
*Use a combo of your stun and flash to get out of situations quick and safely.
Quick Explanation on Setup
Summoner Spells - I chose teleport over the usual ignite for veigar because the goal for the early game is to farm your Q. This means not bothering much to damage the opposing champ. Later in the game you will not need Ignite because your single target AP combo will kill any champ (even tanks) without the use of ignite. Teleport can help veigar get around quicker, especially if you teleport to a turret because of the less cooldown.
Starting Items and Runes- With the mix of these, you will find that you barely run out of mana, which is very important early game. This will allow to farm your Q. Then once you recall, you can teleport right back to your turret (which is why boots are not a starting item, but a first back item).
First Back- Gives you more mana and grows, so by about 30-35 mins in, you should be able to purchase Seraph's Embrace and have it upgraded right away.
Core Items- Most people use sorcerer's boots, but I prefer Ionian boots because of the cooldown reduction (either item works). It is important to purchase Rabadons Deathcap first, this way you deal more damage in general. Also with this item and the level you should have DARK MATTER, you should be able to kill groups of minions quickly, gaining you fast money. You should be doing hit and runs at this point to damage champs or help out in team fights (you can kill champs now too with your full combo).
* Once you get Deathfire Grasp, it's over for any champ who you can stun. A quick combo of E,W,Deathfire Grasp,q, then R. This should kill any champ.
*Seraph's Embrace should be able to give you about a 600 health barrier, which can help out a lot when you need to escape or want to safely kill a champ then escape.
Abilities - Need Baleful Strike first, then stun for protection early on. At level three, you don't need Dark Matter because of the small amount of damage it does and because your stun will not last long enough to let Dark Matter hit. Put a second point into Baleful Strike in order to farm faster and do more damage, and still focus your fire on minions. At level 5 and 7 you should put a point into Event Horizon so that you can land your full combo by level 7. From there on, max out Dark Matter because it will become very useful for killing minions quickly, making champs run away, or causing severe damage in your combo.
Character Matchups - From
First off, Bashyour*** has a great detailed build on veigar. The main difference is the items I prefer and the use of teleport instead of ignite. His character matchups are perfect and I would like to include them in mine as well. For much more detail and description on veigar, you should visit Bashyour*** guide "Veigar, The Overpowered Underrated Midget Of Doom."
Ahri - Difficulty: Medium
Before level 6, Ahri shouldn't be much of a problem. It's very important to dodge her skillshots, especially Charm. After level 6, she instantly turns into this triple-flash-mobile firefox thing that can dash here and there using her Spirit Rush, dodging your stun and messing up your combo. VS Ahri it's best to spec a few points into Event Horizon to guarantee that "STAY THERE AND DIE" concept. It's important to note that although she can ulti out of your stun circle, she will still get stunned, so try punishing her for getting caught by nuking her down, or atleast getting a Baleful Strike in there somewhere. You may want to pick up Chalice of Harmony against her if you're having trouble. Having a jungler with a stun on your team could really help you put down your Event Horizon. For example, Amumu ganks with his Bandage Toss and (hopefully) he gets Ahri stunned. That 1 second stun gives you the opportunity to follow it up with your stun, and you should be able to nuke her down completely after 6 (or after Deathfire Grasp).
Akali - Difficulty: Easy
Like Veigar, Akali is pretty much useless up until level 6, when she gets her Shadow Dance. She will be focused on farming as much as possible (Just like you are) and will plan to mess with you once she hits 6. VS an Akali it's best to keep the minions more to your side of the turret. Even if it takes a few hits, it's important to feel safe under your turret, because if she dives and you place your stun correctly, it's an easy kill for you. Also make sure to call SS/MIA if Akali decides to roam. When she uses her Twilight Shroud try throwing in a Dark Matter in there if you have the mana to afford it. Before 6, you may want to autoattack-harass Akali just a tiny bit to let her know that you're in charge of the lane.
Anivia - Difficulty: Hard
You could already guess why Anivia is one of the hardest champions to lane against. Her damage before level 6 is insane. She can stun and she can slow. After level 6 she has the ability to zone you viciously with her Glacial Storm and threaten to kill you if you come close. What's worse is, Anivia will generally have more farm than you, and will most likely build a Rod of Ages early on which will soak up your nuke quite a bit. Even if you do manage to kill her with your nuke, Guess what, She turns into that egg ( Rebirth) for a few seconds and will come back to life unless you nuke her down... again, Which is quite impossible unless you have someone helping you. Generally speaking, Anivia will torture you, and you will hate your life, but the best thing you can do is farm and wait for the late game. If you can't beat it; Stall it.
Annie - Difficulty: Medium
Annie is a midget that can nuke you too. She has the ability to Flash-Targetlock Stun and follow it up with huge damage. It's very dangerous to go anywhere near her. Before level 6, most Annies would last hit with their Disintegrate, because it gives them a full mana refund and when they build up to 4 spells and have their stun ready, they'll most likely stun you and follow up with an Incinerate. ALWAYS look at her stun icon, you NEED to know if it's ready or not. This is more of a skill match-up than "This counters that". Simply put, the first to be stunned loses the fight (Assuming you both can nuke each other down).
Brand - Difficulty: Easy-Medium
Brand is another strong mage with a stun and one of the best AoE nukes in the game, But be alarmed. he can also nuke you down using the bonus Pillar of Flame damage and his Pyroclasm that may bounce to you up to 3 times after level 6. Brand will push his lane by nature, and will try and harass you with Sear and Pillar of Flame. Make sure you dodge them. As a squishy mage, you can't afford to take that kind of harass. It's best to farm and wait until endgame. The good thing is, Brand has no escape spell, so a good guaranteed stun on him combined with your Deathfire Grasp + Nuke will surely take him down easily. *Beware of his Conflagration, the spell that spreads fire everywhere. I also main Brand and I notice a lot of people don't pay attention to his spell. If you see one of your friendly minions on fire, stay away from it, he will likely use Conflagration on it and spread it onto you*.
Cassiopeia - Difficulty: Medium
Cassiopeia is a real lane bully, with a lot of damage over time spells that are spammable (and cost less mana each time). Try to avoid getting hit repeatedly with her Noxious Blast because her Twin Fang will be spammed, and your health bar will go down. Before level 6, your main issue with her is the harass. After level 6, your main concern is her Petrifying Gaze. Cassiopeia isn't much of a nuke champ, but considering your squishyness she may very well go all in with Damage over time spells and an Ignite to top it off. The good thing is, your stun range is longer than hers, so use it to your advantage. She has no escape, so if you can guarantee a stun after 6 and Deathfire Grasp you can guarantee a kill.
Cho'Gath - Difficulty : Hard
[cho'gath was created specifically to destroy you. He can knock you up with Rupture, Silence you with Feral Scream, and sustain all he wants with his Carnivore. It's absolutely crucial to dodge the knock up. If you get caught out of position once, you might take some serious damage from his combo, if not die to it. Cho'Gath is scary after level 3-4, where he has all his spells; a good amount of CC and damage. 9/10 May seem very difficult, but it's only high because of the skillshot-dodging. Dodge his Rupture, Avoid his Feral Scream, and you are sure to win this lane. He is not indestructible, He is beatable, he is gankable, he is nukeable. Depending on whether he tanks up or goes offensive, you will still be able to do a moderate amount of damage and even nuke him down completely if you've been farming well. Overall, Dodge CC, Farm, Nuke.
Diana - Difficulty: Medium
Diana is similar to Akali, except she has Pale Cascade to protect herself; But since you won't be playing offensive, her shield will feel a bit useless and she will most probably start to level up her Crescent Strike spell. This means you may take more damage, but will also allow you to inflict more damage since her shield is weaker. Dodge her skillshots before level 6. After level 6 she becomes a nightmare like Akali. Make sure you stay near your turret and farm until you get a good instanuke opportunity.
Fizz - Difficulty: Medium-Hard
Fizz is a slippery son of a fish. He can literally dodge your entire nuke with Playful / Trickster (Which goes down to around a 6 second cooldown with a bit of cooldown reduction). Before level 6 he will try as hard as he can to get that Sheen. Once Fizz gets Sheen and level 6, you better prepare yourself for the worst. Alot of people think that Fizz is the ultimate counter to Veigar, but I will try my best to explain the strategy that I use to beat him in lane. Before level 6, everything's good, you're farming, he's farming, etc. After level 6, it gets dangerous. Always prepare your stun in a way that if he decides to attack you, he'll be stunned as soon as he dashes to you. Also, when you have blue buff (CDR and Mana Regen), you can use it to quickly shoot out Baleful Strike. The idea is to bait his Playful / Trickster using Baleful Strike over and over again. If a Fizz is smart, he'd wait for your ult then use his Playful / Trickster to dodge it, but you're going to be just poking him with your Baleful Strike since it has a low cooldown with blue buff and sooner or later he's forced to either 1) Jump on you and attempt to destroy you, or 2) Use his Playful / Trickster to avoid the Baleful Strike. In scenario 1, As mentioned previously, defend yourself with your Event Horizon and attempt to start harassing him until the same situation happens. In scenario 2, He's now VERY vulnerable. A good Event Horizon followed by your nuke will completely destroy him. Top off your nuke with an Ignite and he's a gonner.
Galio - Difficulty: Medium-Hard
Galio has great harass and team fight presence. His early laning is a bit horrible, so take advantage of it by farming safely. Once he hits level 4-5, his pokes start to get more dangerous. Dodge every skill shot (Resolute Smite and Righteous Gust). Most Galios will spam their spells to farm and end up pushing their lane by doing so. This is somewhat good for you, as long as you know how to farm under your turret, it should be fine. Galio is not the easiest mid laner to nuke down, so it's best to take it slow, farm your AP, and maybe try and roam bot lane or top lane for ganks. Ganking will be difficult however, since his mid lane pressure will be devastating. Your only option is to stick to your lane and farm until there's a team fight phase. It all depends on the game flow, but generally you will not be able to nuke him down if he stacks magic resist. You can try and poke him with Baleful Strike but if it doesn't do much, save it to farm.
Gragas - Difficulty: Medium
Gragas Barrels are too strong to ignore. They are very hard to dodge, and surely you won't dodge all of them. Before level 5 Gragas isn't much of a problem. After level 5-7 his ultimate will be ready and his barrels will take down 25% of your hp. Nothing is stopping him from Body Slam into you and nuking you down... Oh wait... There is something stopping him, Your stun. Play it safe as usual under your turret, Farm up real good, and wait for the nuke opportunities. Gragas is usually pretty squishy so after Deathfire Grasp and your Primordial Burst you'll be able to take him down easily. Bring a lot of Health Potions, you'll need them.
Jayce - Difficulty: Medium
Jayce is one of those champions that either do really well in a game, or really fall behind and become useless. His main source of damage comes from his Acceleration Gate Shock Blast combo. Dodge that, and you'll be doing just fine. If he doesn't build a Hexdrinker, you can easily nuke him down after Deathfire Grasp. This should be an easy match-up, but if you have trouble, you can always call on your jungler to help you gank, or you can pick up an early Seeker's Armguard and buy Health Potions.
Karthus - Difficulty: Very Easy
Karthus is one of the easiest champions you could go against. He is probably more squishy than you are, and will try to focus on getting more farm than you. I think this is the only exception where you might actually want to poke him with your Baleful Strike when you hit level 5 and have it at rank 3. You'd be surprised at how much damage it deals. After level 6 alert your team that his ult is ready. Bring some Health Potions if you can't dodge his Lay Waste, and destroy him with your ult whenever you have the chance. Use your stun to stop his Requiem from channeling.
Kassadin - Difficulty: Hard
Kassadin will most likely silence you with Null Sphere whenever it's off cooldown and focus on his farm until he gets to level 6. Most Kassadins tend to build Tear of the Goddess and Catalyst the Protector early on, so they won't be doing much damage. It becomes a problem when they start to do Riftwalk-Damage combos and you won't be able to retaliate because you're silenced. the best way is to poke with Baleful Strike after you get Deathfire Grasp until he gets to around 60% hp, then proceed to get a good stun on him. Kassadin can Riftwalk through your stun without actually being stunned, so beware of that. Hug your turret, Bring Health Potions, Buy a Chalice of Harmony if you're getting destroyed, Farm AP.
Katarina - Difficulty: Medium
Katarina is one of the weirdest champions to lane against. 7-9 is a big difficulty range considering the previous champions I talked a little about. This is because some Katarinas are really good at dodging your stun by Shunpoing out of it, and appearing right behind you when you plan on going to nuke them and miss your stun. Katarina pre-6 may decide to farm with her spells, or may decide to play aggressive and poke you with Bouncing Blades. Buy some Health Potions, Farm up your Baleful Strike. She cannot tower dive you. After level 6 you have to bait her. It's very risky to try and go in and stun her, because if she Shunpos behind you and does her ult, you're pretty much screwed and you can't stun her because it's on cooldown. The best way is to 'bait' her. Let her bring the fight to you. Wait for her to Shunpo to your location (Behind you) and with your super-ultra-fast-midget reflexes put the edge of your stun in the same area. This will stop her combo before it even starts and may even stop her Death Lotus if she was quick with it.
Kayle - Difficulty: Medium
Kayle before level 6 isn't much of a difficulty. She will just naturally push her lane with her Righteous Fury. Tell your jungler to gank before she hits level 6. After level 6, she has the ability to absorb your entire nuke with her Intervention. It's important to realise that she CANNOT cast her Intervention if she is STUNNED. Most Kayles will go full glasscannon (full damage, no defense) because they rely on their Intervention to protect them. Spec a few more points into Event Horizon rather than Dark Matter, those extra stun seconds will ensure that your nuke will be done before she even gets out of the stun. This shouldn't be difficult. Farm early, Destroy her after level 7 and top it off with Deathfire Grasp and Ignite.
Kha'Zix - Difficulty: Medium
Kha'Zix is an annoying champion that is not dangerous, but rather 'weird'. I haven't faced many Kha'Zixs to know the ins and outs of how to beat them, but generally they can't really kill you because even if a Kha'Zix jumps to you, you can just put down the edge of your stun right where you are and stun them before they get to do anything else. Bring some Health Potions. If you take fatal damage, build an early Seeker's Armguard. You may be able to nuke him down if you've farmed enough early game and if he doesn't pick up a Hexdrinker. Most of these match-ups are just waiting for the right opportunity.
Leblanc - Difficulty: Medium-Hard
LeBlanc is one of the most annoying mid laners, specially against Veigar. Her Sigil of Silence- Distortion combo is too strong to ignore. She will harass the hell out of you. Bring a lot of Health Potions and itemize for Chalice of Harmony if needed. (You may want to pick up a total of 3 Doran's Ring aswell). Leblanc is a nuissance at all levels after level 2-3, so beware. Farming will be difficult when she comes to harass you. You can still nuke her after level 6 and Deathfire Grasp, if your stun is aimed cleverly. When Leblanc uses her Distortion, she is likely to go back to it, So you might want to put your Event Horizon Edge of the circle stun right on the position that she will teleport back to, so that as soon as she re-activates distortion she gets stunned, and by then you would have prepared Dark Matter, followed by a Baleful Strike to retaliate the harass. Stay near your turret and play defensive most of the time until you see a window of good opportunity. Her Mirror Image will not "block" or "dodge" or "absorb" your nuke, so keep that in mind.
Lissandra - Difficulty: Medium
Lissandra can harass very well, and may blink through your stun using her Glacial Path. Before level 6 she's not really a dangerous champ to lane against. But after level 6, she might use her Frozen Tomb to make herself invulnerable and dodge your nuke. The best way to beat her is to poke her down with Baleful Strike after you've farmed a considerable amount of AP early on. Poke with Baleful Strike repeatedly, test your damage, test her defense. She may Glacial Path right into you, stun you, and destroy you. Bring Health Potions, Buy Chalice of Harmony if needed, Stay under your turret and wait for a good nuke opportunity.
Lux - Difficulty: Medium-Hard
Lux's spells are very hard to dodge, considering your movement speed is low early game without boots. She definitely outranges you, so you might not want to start any fight early on. It's best to farm until you get Deathfire Grasp, then try to flash in, stun, and do your combo to finish her off. She has no escapes, so killing her should be easy peasy. Bring a few Health Potion, Buy Chalice of Harmony if she pokes you down with Lucent Singularity too much. Remember, Lux specializes in poking, Veigar specializes in nuking, So if you're gonna fight, go all in.
Malzahar - Difficulty: Medium
Malzahar's spellkit is hard to control, but if controlled properly, is one of the most dangerous combos in the entire game. He can Silence you with Call of the Void, use Null Zone and then suppressing you with his Nether Grasp, with Malefic Visions and Ignite going off, it's some very deadly stuff. He will push your lane and create pressure on mid lane with his Malefic Visions. Always beware of friendly minions around you that are about to die with the Malefic Visions on them, because they'll spread to you. The good news is, Malzahar is very nukeable as long as you position your stun right. Your Event Horizon stun range is longer than his ult range, so you have the slight advantage in this fight.
Mordekaiser - Difficulty: Easy-Medium
Mordekaiser is a melee mage that can use your own minions to give him a shield with Iron Man. When you see your minions attacking him with you, you automatically assume you have the edge because there are more things attacking him, right? Wrong. He will literally fill up his shield by dealing damage to every single minion (All his spells are AoE), and it will be incredibly hard for you to nuke him down. Mordekaiser will push his lane by nature, in order to keep the shield up and farm. You will be farming safely under your tower. Pick up a few Health Potions. Chalice of Harmony is not worth picking up for this match-up, but if you need it, by all means get it. Tell your jungler to gank mordekaiser early on in the game, he literally has no escape mechanism and is very vulnerable to a good gank. Don't hesitate to tell your jungler to babysit. Your best bet is to farm as much as possible early game, and after level 6 or Deathfire Grasp, go all in and nuke him down. My advice : Wait until his shield is down, then go in. The best time to go in would be when both sides of the minions are meeting each other, by then his shield would have decayed by a bit (if not all) and your job is to nuke him down before he can get to your minions and fill up his shield again.
Morgana - Difficulty: Hard
Morgana will push your lane, Morgana will sustain. She can walk through your stun with her Black Shield, so good luck trying to nuke her down. Honestly, A good Morgana will never get herself into a position where she'd be 'caught out'. Quite frankly, you cannot nuke her down. Sorry dude :(, but what you can do is farm your permanent AP under your turret. Sounds like fun eh? Focus on roaming top and bot for ganks, but beware... Morgana creates a lot of mid lane pressure with her Tormented Soil and Soul Siphon to sustain it. You may want to try and poke her with Baleful Strike after you get Deathfire Grasp and maybe try and all in her when she gets to around 60% health.
Nidalee - Difficulty: Medium
Before level 6, Nidalee will be focused on farming, and Bushwhack nearby bushes, so alert your jungler. At level 5 and onwards, you'll notice a drastic increase in the amount of Javelin Toss harassing... Specially if she's picked up some mana regen items early on. Each Javelin Toss will deal around 34% of your health, so bring a lot of Health Potions and dodge them as much as you can. Stay behind your minions. After level 8 or 9, her spears become really deadly and will do up to 65% of your health if she's well fed. Again, you have to buy Health Potions and play defensive under your turret, and nuke her down whenever you feel like there's a good opportunity. Nidalee's Cougar can Pounce through your stun but will still stun her at the place she lands on. You may want to pick up a Chalice of Harmony.
Orianna - Difficulty: Medium-Hard
Orianna has relatively low cooldowns. She will try and harass you with her ball as much as possible (Command: Attack and Command: Dissonance), and they're very hard to dodge. You might want to pick up a Chalice of Harmony and 3 Doran's Ring with a few Health Potions to sustain her poke. If you could dodge her spells that would be great too. Pre 6 she's a nightmare, After 6, she's more of a nightmare. She has really good team fight presence with her Command: Shockwave. Warn your teammates not to stay grouped up in one place as her ult can change a team fight entirely to her favor. In lane, focus on farming as much as possible and wait for the right time to all-in nuke her.
Ryze - Difficulty: Medium
Ryze is very weak early game, Sounds like another champion we know. Ryze relies heavily on farm, he is an endgame carry. It's absolutely crucial to find the opportunity to nuke him down between the time that he 'starts to get dangerous' and the time that he 'completely destroys everything'. Your job is to shut him down early, making it hard for him to come out on top in the end game. But early game, you have to farm, so how do you know when to all-in nuke him?- When you get Deathfire Grasp: It's a gift from Riot especially to Veigar. Abuse it. If Ryze builds Spirit Visage follow it up with a Void Staff. If he builds Banshee's Veil then i'm sorry mate but you're going to have to bait it with your Baleful Strike. As usual, farm your AP, test his defense out once you get Deathfire Grasp, and nuke his punkass down.
Swain - Difficulty: Medium-Hard
Swain is one of the hardest champions to lane against, as his ultimate Ravenous Flock provides the ultimate sustain. Before 6 Swain may try and harass you with his damage-over-time spells ( Decrepify and Torment). Make sure you dodge his Nevermove or else you'll take some serious damage. Be equipped with a lot of Health Potions, 3 Doran's Ring, maybe a Chalice of Harmony. Farm your AP until you feel like you are able to take him on, then all-in nuke him with your Ignite (IMPORTANT). Ignite is crucial to stop his ult from healing him a lot. You may want to test his defense with a Baleful Strike before you go all in. You may also want to wait for your Deathfire Grasp.
Syndra - Difficulty: Medium-Hard
Syndra has good poke before level 6, so make sure you dodge all of her spells ( Dark Sphere and Force of Will, ESPECIALLY her long range stun Scatter the Weak. If you get stunned, she'll likely follow it up with a slowing ball of doom followed by her ult nuke ( Unleashed Power). If she gets that combo on you, you are most likely dead. You may want to pick up 3 Doran's Ring and a Chalice of Harmony if necessary. As usual, farm AP, and wait for good nuke opportunities. Pick up a few Health Potions.
Talon - Difficulty: Medium-Hard
Talon is "One of the best counters to Veigar" which is true in some sense, but false in others. If you're farming your AP under your turret, then you shouldn't be afraid of anything. Talon can't dive you, and if he's foolish enough to do so (Assassin's Greed), you can just stun him and let the turret do all the work, picking up the kill. Before 6 he will try to harass you with Rake. After level 6, he'll try and destroy you. Bring Health Potions and build an early Seeker's Armguard. Tell your jungler to gank Talon before level 6, as he has no real escape mechanisms other than his blink. You can nuke him down if you land a good Event Horizon followed up with Deathfire Grasp if he hasn't bought Hexdrinker.
Twisted Fate - Difficulty: Medium
Twisted Fate early game will dominate you; Pushing his lane, harassing you with his Wild Cards (Which is dodgeable by the way, so dodge it). Alert your team when he hits level 6. You may want to pick up 3 Doran's Ring and a Chalice of Harmony if necessary for this match-up. Your job as Veigar VS Twisted Fate is to farm AP, and play it safe until you get Deathfire Grasp. After DFG, Feel free to spam-insta-nuke his bottom over and over again for free kills. He is unable to nuke you; he just doesn't have enough damage. Be sure to outrange him with Event Horizon and don't go in if he has his gold card ready.
Vladimir - Difficulty: Medium-Hard
Vladimir is basically useless until he hits level 9, when he has his max rank Transfusion ready, but is still quite deadly after he hits level 6. He can use his Sanguine Pool to dodge your nuke (including your super duper ultimate) so situationally, you have to bait it out. Farm your AP with Baleful Strike early on, and once you're powerful enough, try to poke him with Baleful Strike, test his defenses. Spec a few points into Event Horizon rather than Dark Matter. If you feel like you can nuke him, do so. You may want to bring 3 Doran's Ring and a Chalice of Harmony if necessary with some Health Potions. You don't necessarily have to bait out his Sanguine Pool, he can't use it when he's stunned anyway, but if you have some delay issues (if you panicked, etc), he can pool as soon as he gets out of stun while your ult is flying towards him and your ult will end up getting cancelled so beware. Use Ignite to reduce his heals if you're going all-in nuke.
It's recommended to bait his Sanguine Pool before you go all-in, otherwise your spells will be on cooldown and it will hurt your game.
Ziggs/Zyra - Difficulty: Medium
With these champions, it's all about dodging skillshots, Ziggs's Bouncing Bomb, and Zyra's Deadly Bloom Grasping Roots) and finding the right opportunity to go in and instanuke them. They're all relatively squishy, you can nuke them down by level 7 with Ignite guaranteed. Their early poke is dangerous, however, so bring some Health Potions. Don't be afraid to go for 2-3 Doran's Ring. For individual tips: You can farm your Baleful Strike onto Zyra's plants and I encourage you to do so. Ziggs "escape" spell ( Satchel Charge) will take a bit of time to activate, so use your stun on him and nuke him down.
Xerath - Difficulty: Medium
Xerath has recently received a rework, but most of his abilities have remained similar. For this match-up you may want to even start with boots and a few pots to dodge his poke. Pick up a chalice of harmony if you get too bullied. In my opinion Xerath is relatively "useless" compared to Veigar in teamfights/nuke potential even though Xerath will push you (or try to push you) out of lane. While he's charging his spell, he gets really slow and that's when you should go in (after 6). If he's got Chalice of Harmony you might want to poke him with Baleful Strike first to see if your nuke will be enough. In general, Xerath has long ranges and will position himself in a way that's impossible for you to get to him - BUT. If you finish off deathfire grasp and have all your cooldowns, wait until he charges his spell then go all in and destroy him. You also have to watch out for his single-line-missile stun, but yours should last longer at later ranks.
Zed - Difficulty: Medium-Hard
Zed is a melee assassin that will poke/harass you before level 6 with his Razor Shuriken + Living Shadow + Shadow Slash. You may want to build Seeker's Armguard, even starting off with Cloth Armor and 3x Health Potion, 2x Mana Potion. Zed can be quite dangerous once he hits 6, and unless you know how to counter his assassination combination, you're in for some deep sh*t. When he ults you he becomes untargetable ( Death Mark) (Yes, he can dodge your ult). However, when he ults you, you should know exactly where he's going to land (right next to you if you didn't know), so you can put down your stun's edge right on your so that as soon as he appears he'll be stunned. For advanced techniques, you may even want to Flash back under your turret (if you're close enough in turret range) and then stun him there, where the tower will help you finish him off. Most Zeds will build a Hexdrinker even if you don't harass them early. If they don't build Hexdrinker, feel free to poke then insta-nuke them.