Not Updated For Current Season
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
As you will probably know about Karma, she can level all her skills to 6.
Well now I use a regular build type, but for 6 levels.
You only need to level the Spirit Bond once, because it isn't a very important skill. You will be using your Heavenly Wave and Soul Shield a lor more. Especially for a great harras.
I take normal runes, all flat runes for an early game advantage.
So I just pick AP Quints, for the good 15 AP at the start.
Then I pick 9 Magic Pen Marks AND Glyphs.
At least I will need my mane, so I take 9 Seals of Mana Regen.
Those are the runes I recommend you to use.