Karthus the best way
Not Updated For Current Season
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
Just buy your items and go to mid lane,or what ever lane you go to, always make sure you help your jungler look for invade and leech for your jungler so you can have a better chance on getting second blue. In order to last hit with karthus be sure to just try to hit one minon with q and not mutiple minons.
Ah heres the fun part as long as you have your seraph's embrace and zhonya's hourglass be the tank your team doesn't need. Go straight in making sure you have your defile(E) active zhonya's to make your self alive longer and use seraph's embrace too, when you die you can ulty depending on if the enemy team are low health.
Exhaust those two summoners will help the most honestly because since you have your ult you wont need ignite to finish off your job
you can also take teleport instead exhaust
Oh yeah in rank games dont go like a yolo monster in Mid Game and Late Game because it can hurt your team in the end
You go the certain mastery i put on there because you want to try to maximize your dmg, you can also go for 21/0/9 for the mana regen and longer buffs time
Go those runes magic pen marks increase dmg output, health seals give you a little more substain, ap glyphs and quints gives you more dmg, you can change the ap glyphs to mr glyphs if you feel you are squishy and need substain vs another ap