Not Updated For Current Season
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
Just enjoy.Some tips DO NOT GO INSIDE A GROUP FIGHT stay outside.Remember when they hunt you and you can't escape just pop up a Wall Of Pain and nuke him with Defile also if you playing karthus for first time remember to have some practise at Lay Waste.Also try to have a partner with you (Prefer Garen or Sion).Also your Wall Of Pain it's a very useful for hunting enemy champions and save your ***.Try to avoid getting in fight with melle players without having support.Also when they hunt you pop up Defile to do more damage,and then finish them with your ulty.Our ulty Requiem is the best way to get free kills use caution becuase it has very long cooldown(Be carefull becuase some players have magic resist and you may not succed to kill them with your ulty).Thx for reading my build.I hope it will help everyone who play's Karthus feel free to comment! :)