Miss Fortune Build
Not Updated For Current Season
I may have messed up the skill order in the early teens, it really depends on who you are fighting as to which skills are more useful, but powering up Make it Rain is very important.
You should get a mana potion to start with too, and any time you port back, pick up a couple more. Until later game, mana will be in short supply, so every time you kill your opponent mid-lane, or they run home to momma, you should port back, refill your mana and buy more stuff. Use ghost, and you are fast enough that you can get to the middle first every time.
As to play, in early game be sure and get as many minions as possible inside of MIR as well as your opponent. Try not to auto-attack too often and get last hits in for the money. When your opponent is worn down to below half, and is hiding behind a screen of minions, pop him with double shot, MIR, and Ignite. He'll be dead in a second.
In late game, you will be able to take out the guardian monsters easily and getting the blue and red buffs is a good way to make your team fights one-sided. Any time you can get three opponents in your Bullet Time, let-er-rip.