Your first thought after seeing this guide is probably, "WTF Smite on Liss mid?!?" Don't worry it'll make sense.

This isn't a full Lissandra guide. If you want that look elsewhere. This is a guide on how to use your ability with Lissandra and take it a step further with a mildly harder build that brings much more potential reward.

This guide isn't meant to be too in-depth, nor have I ever really made a guide before. So I'll keep it short and sweet.

First off, keep in mind that if you have the enemy poked down enough when you hit 6, you have a strong enough power spike to all-in and get the kill.(This becomes much more possible after you get RG.(<4 sec deletions)

With 5.12's addition of Runeglaive, it makes a huge change to the potential Lissandra. If you smite their ADC(or other target) after an E + W initiation, then R if needed and Q + auto every cooldown they will drop faster than anything. The first burst will stun the enemy team as well as do a nice chunk of damage. The RG's will not only keep your mana under check, but will deal extra damage to the target with the 4 second Challengers and also the spellblade will get some extra damage to the enemies around them.

Also the second smite means you can Dragon or Baron more safely as well as have the extra potential to steal Drag/Barron and counter jg when you decide to roam.

Also remember that no guide is set in stone. You don't have to follow this guide to the letter(technically you don't even need to follow this guide at all). Changing items to fit your situation is a must in games.

If you made it all the way down here, thanks for checking the guide out. If you have any questions I'll do my best to answer them.
-Mango