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You may want to focus your runes abit. Maybe search for Searz's Rune Build, since your glyphs are not too good. Maybe focus all your Quints and all your Glyphs to be the same type?
Manamune is not necessary. After getting Sheen and reaching level 11, Mana problems should be a thing of the past.
Boots of Swiftness is also not neccessary. It may be taken, by Ionian boots help early on, Zerk Grevies in mid-late game, Merc/Tabi helps all the time.
Your items cancel out your boots. You may want to look into that.
Overall good Tank Nasus build. Despite having Infinity and Manamune, your damage lies in Siphoning strike instead of your damage items.
@Baxxie
That doesn't work. Infinity Edge works on Nasus who constantly hit their targets to oblivion. Getting Youmuu might be good, but Frozen Heart is ****. You don't NEED extra armor when your magic resist part is ****py. CDR is ******ed. To spam W, I find it wasted. A good AD Nasus can easily kill anyone by just Siphoning strike twice and lots of hitting, with or without slow. If you constantly spam W, you won't even be able to charge up for your Q, which isn't good.
Also, Inf Edge, wtf. Get Youmuu's or Frozen Heart for some CDR, so you can constantly W.