Not Updated For Current Season
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
For the runes I use attack speed... I use to use att dmg but his Q isnt really a damage spell, its more of a chase spell, so I use attack speed cause of passive, so if im in a 1vs1 situation I get my passive heal faster.
For masteries I go for standard attack and utilities masteries, utilites masteries might seem strange but I think the experience boost really gives you level 6 faster so you can gank more often and get feeded fast.
I start of with vampiric scepter, so I can stay in lane until I get 1650 gold for my BF sword, after that I rush for the bloodthirster and boots and farm a bit so I get my BT stacks up to max 40dmg. After that I go with the standard critical items, phantom and infinity, I start it with zeal cause of the movement speed for chasing. After that I get my secound phantom so i get a lot of critical chance. The last item depends on the opponent team, i usually buy another bloodthirster or black cleaver, but you can also buy banshee if your playing versus a nuke AP like veigar or leblanc...