AD Bruiser Vayne
Not Updated For Current Season
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
Why this build works
WILL BE UPDATING SOON...
The simple reason why this build works is because of silver bolts. Vayne doesn't need much damage and can rely mostly on silver bolts and some attack speed to out trade most people.
The problem with playing Vayne is she doesn't have much range and needs get close to enemies to do damage. However, by doing this you become a target and die very easily since you are very squishy. This build eliminates that problem. You can now stand up close and take a lot of damage but also dish out a lot of damage.