This build is my most common Nidalee build. I generally play her as support because I feel she fits this role for teams better than most of her roles. Nidalees most significant downfalls are contributed to not being good with team compositions unless she is with a poke team, I play her as support so that top can be a more efficient bruiser for the team while I can still provide useful support.
My rune build is fairly simple. When I play Nidalee I prefer to set up for a kill lane, or a lane that can harass and farm efficiently. So I maximize my DPS with magic pen and pure AP. The mana regen is almost a necessity because of Nidalees massive mana consumption early game, if you do not want mana regen and want to go for a more passive support build I suggest going for flat armor yellows.
My masteries are setup to maximize mana regen, CDR, and AP DPS. Mostly revolving around Spear consumption.
My items are setup to have good early game mana regen and slowly balancing out to have a decent amount of AP.
Archangels - Probably my favorite item in the game. Early tear makes it so losing mana is almost impossible because all of Nidalees cat form abilities scale with its passive and do not cost any mana.
Sherelias Reverie - Just a classic support item. Good GPS and very useful speed buff for chases. A must have for early game if you expect to stay in lane for long periods of time.
Rod of Ages - Your bread and butter of damage, since you are support you wont be making much gold for items, your RoA with a full 10 minute passive filled will assist taking massive chunks of damage out of your enemies.
Sorceres Shoes - This is just preference, since I go for a kill lane I enjoy the magic pen, but you can easily replace with for more defense with no objections.
Summary - These are just the core items of this build. When you finish this build, everything is up to you. After the build is complete you need to decide how your playstyle is going to fit the team and buy the right items accordingly.
Summoner spells are just preference for me.
Heal - Used for 2 reasons. 1 - I maximize spears before heal making heal almost useless until mid game. 2 - You and your teammate almost for sure will not have as much sustain as the enemy bot lane. With meta game supports like Taric/Soraka/Alistar you will have alot of trouble keeping your mana up and sustaining yourself in lane.
Flash - Not much to say, helps with escapes and being aggressive, it's the best of both worlds for Nidalee.
Nidalee is commonly used in poke builds. When I play with friends I always match bot lane up with teammates that can effectively farm and produce the same poke that I can.
Sexy teammates = Kog'Maw, Varus, Caitlyn, Sivir, Corki.
You want champions that can harass just as well as you can and still focus on their farm. Since you are going to be poking at long range, you wont be able to kill the enemy unless you hit your kill shot, they will already be a screen away by the time you get them down enough to have a real fight. Which essentially means if your carry isn't farming then you really aren't going to get much done.
There are a lot more champions that can run with Nidalee and have good harass but not early or far enough range to have an efficient early game kill lane.
There aren't many Nidalee support builds that have decent ratings so I thought I'de give my take a shot and see what everyone thinks. Let me know if this build gives the right amount of support and AP DPS that I think it does.
Sorry for not going much into detail like most of the beast builds that are made. I mostly wanted to post the actual build I use and less of how I play Nidalee.
Please let me know what you think :)