Full Build Example (in this order)
Threats to Vayne with this build
|Bard||Pussy bitch champion. Wait for him to leave lane and then kill the enemy ADC over and over. Have fun.|
|Miss Fortune||Dodge tha Q, get tha $$$|
|Sivir||Spam ctrl+3 on her dead body.|
Supports with Vayne
Janna - God tier lane. You want a Janna support as much as you can get one.
Lulu - I've heard people saying Lulu is a bad support with Vayne but she's my personal favorite support. She's got peel and ridiculous poke pressure. I would even take her over Janna because she's hard to **** up.
Nami - Not as good as Vajanna but still amazing.
Thresh - Thresh is pretty good with Vayne because of his peel and the pressure that he provides. Even if your Thresh is trash you should be able to carry the lane.
Morgana - Decent. Ideally you want something with more peel but you'll take it over a mage support.
Mages - Mage supports are pretty popular right now and will probably get even more popular in season 7. They're good for providing pressure, but can be easily beaten by lanes who know their tricks, so just be aware that you're not safe when your mage support has cd's.
Soraka - Not as good with Vayne as most people think. Since she has to stay behind you to survive, you don't have much lane pressure. However, you win lane in the long run as long as you keep trades short.
Sona - 50/50. A Sona with good positioning is nice, a Sona who doesn't watch where she's going and gets blown up instantly is a forfeited lane.
Leona - Can be good if she peels you, but generally bad since she has one gimmick - go in and leave you behind.
Blitzcrank - Can be good if he consitently lands hooks and applies pressure.
Taric - Terrible.
Bard - See if you can get your support to play LITERALLY ANYTHING ELSE, and if he won't then either ban Bard or dodge. I'm not kidding.