Seriously Must TRY. Too strong
Not Updated For Current Season
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
Everyone thinks Vladimir got nerfed but that is only because they are building him like the old Vlad. This is a legitimate build now and is a lot more powerful I would say than before the rework. You can switch out Banshees for Randuins Omen depending on team composition. With the rework, Vladimir does too much damage to himself if he tries to use E early game, which is arguably his most powerful skill. By going with full hp/tank items, mid to late game, E will be highly "spammable". Since Tides of Blood scales off of hp, I definitely recommend my build. Vladimir will have more than 5k health at full build easily doing more than 700 damage with each E cast. Recommended combo R>W>E>Q (When its early laning phase, try to minimize usage of E and W if that weren't obvious)
After testing, I highly recommend the Runes and Masteries in Build #2.
Sorry its not an in depth guide but please like if you enjoyed a game with this build. You really won't be disappointed.