Safe Win Win Win
This should you Rush right after in this order
Pros / Cons
This is not finish at all, plz be over, and only look the items, notes and mastery so far plz :) !
This is the rune pages I use for ryze!
Greater Mark of Magic Penetration
Greater Seal of Armor
Greater Glyph of Magic Resist
Greater Quintessence of Spell Vamp
I would say this is the best as we can get now. 6% Spell vamp from Runes, 3% from Mastery = 9% Spell vamp, and with the Spirit Visage item. You will have a total of 11% Spell vamp without use your ultiamte!, is almost a hextech revolver from just stats!