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The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
MR runes will help you at early game because you can die easy with ryze
Magic penetracion to deal for dmg
i play with heal and ignite
But you can also play with Flash/ignite-Flash/ghost
With ryze you need defensive masteries so i choose them as my ryze masteries