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As far as the runes are concerned, I stand by my selection. greater mark of Hybrid penetration isn't that effective given the items in this build. Straight MP is better unless you build Guinsoo's Rageblade or Hextech Gunblade, each relying more heavily on AA. Keep in mind Twin Disciplines, the main incentive for starting with greater mark of attack damage]].
I would not advise rushing Sightstone without having targon's brace + Boots or Amplifying Tome. Having it won't matter if you can't get out from under your tower to place them. Given her lack of healing / regen, sustaining yourself in lane is critical. That being said, Sightstone is essential if you want to maintain an aggressive bottom lane.
I will adjust the build order as I become more familiar with the interface, probably finishing that this evening. Thanks again for your responses.
Using only one or two runes of a type will make no difference, and I don't think you will have the chance to AA that much as a support, so greater mark of hybrid penetration would be better. Try going for something more simple like:
On the cheat sheet don't just put everything on one purchase order. You shouldn't ignore your team and the enemy team and do the same build every time, please, do mention situational items, here is how I think you should divide everything: Starting Items, Core Items, Items to finish first, Final Build Example, Situationals. And please, do Sightstone as your first item, I know you want to be aggressive, but vision is really important for a team, everybody hates going with Nidalee, Lux and etc. support because they never ward, so do me a favor and ward more.
Talk about warding, you don't have a Warding chapter on your guide. Your chapter order is all messy, Runes and Masteries after Creeping and Jungling?
Foxy