Runes is most problem when you play talon talon is good champ but if you have bad runes you are weak.
The best choice with him is to use magic resist and AP.
then AD and Health.
First item you buy is Ravenous Hydra Then Black Cleaver Then GA and last item you need is
Talon is good champ use him when you want 1v1 2v2 or 5v5.
when play with him the combo is r+q+e+w and walk