Not Updated For Current Season
Red - Magic Pen (helps build shields by doing more dps, especially at beginning of the game when every little bit helps)
Yellow - Dodge (helps with defensive masteries and dodge = 100% damage mitigation granted that you dodge) -OR- Armor (helps to mitigate incoming damage whether to your shields or your health. Either or, your pick.
Blue - Cool Down Reduction runes.
Start with Siphon of Destruction. Take a rank in Mace of Spades. Alternate Siphon of Destruction and Creeping Death until maxed (taking your ultimate, Children of the Grave at 6, 11, and 16. Finish Mace of Spades last.
- Ghost is excellent in this build because it pairs well with the Boots of Speed, Randuin's Omen, Shurelya's Reverie, and your Movement Speed Quints. It really keeps those quick moving enemies from getting away with 1 bar of health.
- Ignite - This is of course a must have with Mordekaiser. Nothing like cooking your opponent like a rotisserie chicken with Ignite and Children of the Grave. You just "Set it and forget it" if someone with low life tries to make a run for it. (Love that feeling of killing someone who you can even see anymore because of Fog of War!)
First and foremost - It is to be noted that this build can/will land you with a pretty sizeable amount of armor and magic resist. Armor and Resists mitigate damage incoming to Mordekaiser thus causing attacks and abilities to do less damage to his his health and his shields. This decreases the damage your shields will take, and increasing your survivability.