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Your items aren't really necessary for a Twitch... nor is your Masteries. You should probably change it to 21/0/09 which will make it a little more viable... Twitch doesn't need to have the extra ability power.
Also, your runes don't need so much attack speed. Why? When playing as a Twitch you should have Attack Speed but when you come out of stealth you get a bonus and your ult also increases attack speed, and the cap is 2.5.
Also, Dorans Blade isnt too good for early game, I would swap it for Vampiric Scepter so it can build your Stark's Fervor which isn't really good for a Twitch. I would suggest changign your boots to Boots of Mobility Also....