Welcome to Nasus the Egyptian "Bully" Dog. Nasus has the ability to maintain high damage while building mostly "Tank" items. This guide will take advantage of that ability by stacking Armor, HP, and Magic Resist items to make you one tough dog to tame.

Pros:

1. High Burst Damage even without items
2. Best snare in the game
3. Farming Machine
4. Great Lane control start to finish
5. Able to concentrate on Defensive Items throughout the game

Cons:

1. Low early game gank ability
2. CD reduction dependant
3. Few escape abilities

Summoner Spells are up to you. I like Flash for escapes and Teleport for map control myself but others are just as viable. Ghost, Exhaust, Ignite all have merits. Choose what you like!

The only runes that are really important to this build are the CD reduction glyphs and quints(to some degree). The rest of the runes can be situational/preference. Armor and Hp are both viable for Seals and for marks you can use just about anything really that increases damage. AD, AP, Attack Speed, Armor pen. it's all good. The cooldown reduction is very important to take advantage of Nasus's Q throughout the game.

Here is another place where you can use different setups to achieve the same goal. Personally I like to use the Utility build to further increase your cooldown reduction. CD reduction is the single best stat gained from your masteries and Runes. It is very important to keep the CD of your Q as low as possible so you can stack the damage buff on it and help with last hitting.

However, Nasus is very flexible. A full tank setup in the Defense tree or a Hybrid Attack setup is also viable. I just like the CD reduction of the Utility tree to max Nasus's potential. The gold isn't bad either!

Items, Items, Items...

Sheen early game really increases your damage frontload with your Q. It makes most champions unable to trade skill attacks with you in early game and even up through midgame. Use it to keep control of your lane and keep farming!

After Sheen grab a Catalyst the Protector. Then, finish off your Iceborn Gauntlets at least before mid game. Merc Treads and a Ruby should get you bulky enough to start working towards your Final Items.

After finishing off your Rod of Ages you really need to take a look at your team and enemies to see what you need to finish off the item set. Bulwark is usually a good place to start then build for armor or magic resist depending on need!

Start off with your Q(Siphoning Strike) to begin snowballing the damage stacking on it. You will be capping it first to lower the CD down as much as possible but you'll need to get at least 1 rank in your W(Wither) and E (Spirit Fire) by lvl 3 to control your lane. As with most characters you will want to take your Ult(R) every chance you get.

After Maxing Q you will want to get a few more ranks in E help clear creep waves. No need to max it all the way at this time. With the little bit of AP we get from our item build its enough to clear creep waves till later on.

By lvl 12 you should be pretty beefy and be ready to start "Bullying" everyone around. So your W becomes really important to keep all those ganks from escaping. By the time you max your W no one should be able to escape your grasp!

This is probably the most important aspect of Nasus! He is a pro farmer who is very resistant to harrassment at all stages of the game. Early game you should be using Q to make last hitting easy while buffing its damage at the same time! By midgame your E should be strong enough to start taking out whole creep waves. Early game you need to stay in your lane and farm. Try not to go off ganking other lanes. You have great sustain in the lane from early game and can control a lane from start to finish. Take advantage of that!