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This guide has not yet been updated for the current season. Please keep this in mind while reading. You can see the most recently updated guides on the browse guides page.
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
The best way to play elise is during early game poke the enimies without getting too close. When they are at about 30% health, attack them with the spider ability. I recommend using the R and Q keys.