Not Updated For Current Season
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
This is my first build so please be nice :P!
After viewing the other guides for twitch, I didn't find any that really abused him as such. When I play twitch its not uncommon for me to get 30+ kills and this is how I do it =)!
How to play
I always go mid with twitch, simply because when you know how to play with him he rapes anyone mid.
Now without going into too much detail, its easy to harras the other hero then pull of expunges (which does do ALOT of damage with 6 stacks).
When I hit level 6-7 I consider this ganking time (some people consider this very early, I don't) The good thing about twitch is that its hard to call a missing twitch when hes going invisible at every chance! when you gank a lane, line up your enemies and pull your ulti on em then your e when you hit 6 times, you can dive with your 3 blades (a reason i get them) but dont over-push yourself.
once you get past ganking and everyone is running round like a headless chicken, twitch has the incredible ability to just go round the forest picking strays off, he can beat anyone 1v1 unless they are completly overr-fed, but it takes alot!
Next I will explain my masteries/items/runes:
I am a huge runes fan with 9 dif pages for my champs, for twitch I think flat armor is brilliant early on and a must have (maybe flat health, but when armor is only 205 ip, why bother?) dodge is no good cuz I don't like to rely on situational luck, and it does not synergize with twitch at all. for glyphs I like cooldown reduction for my abush/expunge combo, you attack fast enough, reaching 2.5 cap when you have your madreds/agil potion/greaves + level 5 ambush later on so having ability to spam expunge/poison alot more is nice.
I make my masteries with the following in mind:
I want my expunge to hit hard, I want as much ArPen as possible, and I want to farm extremely well as I am fast item build dependent if I want to carry hard.
My fave bit and the bit that I have not seen posted yet.
I go the standard dorans blade abuse with dorans > boots > dorans > dorans, then I save up for a infin edge.
With my dorans I can turret dive at a low level and get those early kills easy. Sometimes if I am not getting all the kills i need, as soon as I have my bf sword I like to grab an agil pot and just pop it before going into fights!
once I have my bf sword its either straight to infin edge OR if there is a huge tank problem I get madreds (WTF MADREDS WHY NOT LAST WISPER!) cuz you have enough armor pen and with madreds you will cut away enemy hp like cheese!
Any questions let me know, I am not very good at guides just wanted to share I what I consider the best way to build twitch.
NOTES I FORGOT:
If they have alot of damage switch flash for exhaust,
Twitch is better than wards, you should be using him as a scout in the forest/lanes throughout the game try to be un-predictable.