This guide is based as an omage to puffynono, who was the person who first got me into playing twich a long time ago and most of this is heavily influenced by him. (i take my hat off sir).

If you are farely agressive then this is the twitch for you. After testing this build multiple times, I've yet to see it fail. Follow this guide and you will become one of the most feared Rats out there.

As for masteries, I like to set up with a 21/0/9.

And as runes go i prefer AD marks, armor seals, MR glyphs and AD quints.

Deadly Venom
Twitch's basic attacks infect the target, dealing 2 / 4 / 6 / 8 true damage every second for 6 seconds, stacking up to 6 times.

Will rarely ever land you a killing blow, only real use to me is for your other abilities.


Ambush
After 1.25 seconds, Twitch becomes invisible for 4 / 5 / 6 / 7 / 8 seconds. While stealthed, Twitch gains 20% movement speed. If Twitch attacks a unit while Stealthed, he gains 30 / 40 / 50 / 60 / 70 % attack speed for 5 seconds.

Even after the rework, it's wonderfull for running around and gank people. This also makes it rather difficult for your enemies to call an M.I.A. on you.


Venom Cask
Twitch hurls a cask of venom that explodes in an area, adding 2 stacks of Deadly Venom, and slowing targets hit by 25 / 30 / 35 / 40 / 45 % for 3 seconds.

Not much to say about this one, except that is great for stacking your passive
quickly, and without much risk, making your E to do MAXIMUM DAMAGE even quicker.

Expunge
Deals 40 / 50 / 60 / 70 / 80 physical damage to enemies infected with Deadly Venom. Expunge deals an additional 15 / 20 / 25 / 30 / 35 (+0.2 per ability power) (+0.25 per bonus attack damage) physical damage per stack of Deadly Venom on them.

This is your bread and butter. Perfect for your killing blows, harrasing once you've leveled it a bit, and even kill stealing ;)


Spray and Pray
For 7 seconds Twitch gains 300 attack range, bonus 20 / 28 / 36 attack damage and his basic attacks become piercing bolts that deal 20% less damage to subsequent targets, down to a minimum of 40% damage.

Probably the reason everyone hates to see a Twitch on the opposing team. This ability gives you the power to basically run into a 2 v 5 and win as long as your not targeted.

This is where you leave the path of all other sewer rats and make a name for yourself.

You should always be solo middles because your are the best carry in game and you should never doubt that.

Start off with a Vampiric Scepter This should allow you to lane middle for quite a while and keep your health bar topped off.

If played correctly, you should have killed the other carry at least once and should stay middle until you've reached just around 2k gold. Yes, 2k. Blue pill back and get yourself your AS shoes, the Berserker's Greaves and a Recurve Bow. The bow will help you start building towards your Last Whisper. Now if you are having some trouble waiting for 2k gold and are just to aggresive you can port back and grab the Berserker's Greaves although i really dont recomend it.

This is where people will fear you. Run around to lanes and wait untill your enemy lines up, tell one of your partners to initiate making them focus on him. Assure him you are a humble rat and you will insure his survival. Once they attempt to kill him you simply Ulti and watch the carnage. DONT FORGET TO EXPUNGE.
When you have around 1.6k gold, take morpheus's advice and thake the blue pill back to and finish off your [Last Whisper] and if you are doing really well, get a Sword of the Occult. So many twitches pass this item by. But as the slippery little rat bastard you are, you will get away!

This is where you will say "I'm a greedy Rat Bastard. This damage is not enough for me!" Go back and build an Infinity Edge starting with B.F. Sword or Pickaxe. Resume your ganking untill you have enough for whichever item you didnt start with. Then finish off when you have aroun 1.2k.

At this point (if you opted to buy the [Sword of the Occult] you should have anywhere from 14-20 stacks and with your Infinity Edge your base damage should be around 200+. Your crits will be hitting anywhere from 700-1,000.

But what about that Vampiric Scepter. Yes, yes. It's time to upgrade it to an Executioner's Calling . NOTE: If required, you may get this before you finish your Infinity Edge. At only 900 gold this will be a cake purchase.

At this point the game should be close to over. If they refuse to surrender it is up to you to judge what your up against. Alot of disbles? Go for a Banshee's Veil. Not to much disable? Get a Phantom Dancer and watch your rape continue.

Everything up to the Executioner's Calling is a CORE item. It is necessary to make this buiold succesful and ensure everyone will call you a Rat Bastard. NOTE: Be prepared to have people say your OP and that they should Nerf you. Respond nothing, watch them rage and feed off it like the rat you are.

I Strongly recomend Heal, flash, or cleanse. (if you are up against champions with any amounts of cc, and dont even bring up nasus, for gods sake, take cleanse so that you actually can shoot.

Why no Exhaust

Heres why, Although your are the most fearsome thing out there, You are squishy. The Heal is only for fight's in lane when your begining to level. Remeber to use it once around 1 1\2 bars or health or 2 bars of health so your enemy thinks they can kill you. Also remember that at level 5, your expunge will EASILY remove 2 bars of their health with all 6 stacks. Use it as a finishing move if they try to escape or to harass them.

Cleanse. My god do i lol when i see a twitch with no cleanse. Simple as it is, an exhaust or stuns will ruin you and your ulti. This also comes in handy when fighting in lane.