Well, this is my first build, so don't complain if the items section is a little messed up.

As we all know, Twitch is one of the most annoying, hard escaped gankers in League of Legends, but this is mostly about getting kills in YOUR lane and gank whenever you can, not gank all the time, you lose experience and gold that way.

I go with 26/0/4 to get the most out of the offensive tree, and I like the 10% reduced time while being dead, also very good in late game when you are dead for about 70 seconds and you lose the farming and kills you could have gotten the seven seconds you were alive (Not that much, but you get my drift).

Why I don't use armor penetration on ANYTHING in my rune page is because I think you can get enough of that by items in-game. Flat marks for that damage you'll have to compensate for your squishiness with at the start of the game, attack speed is always a necessarity on Twitch, and attack damage per level so that you get a extra bonus of attack damage (even tough it's very small) each level, 11 attack damage at level 18 is the total. All the runes are neghotiable and may be changed, but I see this as the best for Twitch.

I see these items as the best for Twitch, but notice that you are very durable with this build, but when I have gotten my items, there are few that has survived to even get to me thanks to my W, ultimate and occasional red buffs. I see Boots of Mobility, Phantom Dancer, Starks Fervor and Infinity Edge as a must for Twitch, the other items ARE neghotiable for durability and/or speed, maybe a little ability power for the already high damaging Expunge! Mix a little to see what fits you.

I can see how summoners max Twitchs' stealth over Expunge, but for as many kills as possible, I recommend that you max Expunge over Ambush. Same as always with the ultimate, I take it on 6, 11 and 16.

As I had mentioned a few times earlier, Twitch is squishy. So to ensure that you survive the first head-on-head battles, I really recommend that you take Exhaust, and Ignite for the magic poison-true damage combo.

Some spells that is worthy of Twitch is Ghost, Flash, Clarity (for his low mana pool and pretty costy spells) and Cleanse. The others are just silly.

Pros: High damage and good farming.
Cons: The only bad thing with this build is his lack of durability, but that is to be compensated with lifesteal.

The best laner companion, if you are not in mid-lane, is a disabler. Stuns, snares, suppressions, fears and slows are the best ones. No silence here! You could also lane with a supporter like Sona or Soraka. But really, a disabler is better and recommended.

Here is where your runes really come in handy. With the combination of the attack speed/damage and his passive, you will do great in farming if you play properly.

NOTE: Should work just fine 1400</>

Well, this is the end of my build, very first one. Hope this will grant you some wins in future games as the sneaky rat he is... This is all from me! Good luck, and have fun.