Introduction
Hi everyone, this is my guide about Twitch...
Twitch is a poison badass rat who is sometimes mistaken to called food, but in my opinion he is the best AD carry if you know how to play him, so I'll try to teach you how to play him.
Abilities
Deadly Venom -Twitch's attacks infect the target with Deadly Venom, which deals damage each second, stacks up to 6 times, and lasts up to 8 seconds.
This poison isn't for killing people like Teemo's poison, this is only to stack for your 
Venom Cask and 
Expunge
Ambush -After 1.25 seconds, Twitch becomes stealthed for 10 / 20 / 30 / 40 / 50 seconds. If Twitch attacks a unit while Stealthed, he gains 30 / 45 / 60 / 80 / 100% attack speed for up to 10 seconds, depending on how long he was stealthed before attacking.
This ability makes you invisible lucker like you are, you should use it for escaping from ganks,fights,but also to check bushes or Baron for your team and ofc the most important to go behind your enemy's and pwn them
Venom Cask -Slows nearby enemy champions' move speed by 30%, plus 6% per Deadly Venom they have. 2.5 / 3.25 / 4 / 4.75 / 5.25 second duration.
You use this for chasing an enemy, just remember to stack as many Deadly Venom as you can before using it
Expunge -Deals 30 / 60 / 90 / 120 / 150 (+100% of ability power) magic damage to each nearby poisoned enemy, plus 20 / 30 / 40 / 50 / 60 additional damage per stack of Deadly Venom applied to them.
Your bread and butter spell early game, good for last hitting enemy's and minion's, but same as Venom Cask , you have to stack Deadly Venom before using it to maximize your damage
Spray and Pray -Twitch gains 15 / 25 / 35 attack damage and his attacks become long range line missiles for 12 seconds, dealing 100% damage and poisoning all enemies hit. During this duration, a maximum of 5 / 6 / 7 missiles can be fired.
Twitch's ultimate doesn't give attack speed anymore, instead now it gives attack damage which is a lot better (my opinion). You use it when you pop out of stealth to maximaze your Deadly Venom stacks, just remember,when you are stealthed:first 1 autoattack your target and then use Spray and Pray to gain attack speed bonus from stealth
Masteries
There's not much to explain masteries...
Standard AD carry masteries taking
Awareness
, Peseverance and
Meditation
in utility and all major masteries in offense ;)
Items
Let's do the explaining: You take 
Infinity Edge cause of the AD and crit strike so, with 
Phantom Dancer you should have around 90% crit chance which is a lot
Phantom Dancer - great item, stacks good with Infinity Edge
The Bloodthirster -Gives you AD and life steal, just remember too last hit as many minions,monster,champions to stack it's passive
The Black Cleaver -Gives you Attack damage and Attack speed, remarkable, with this and a Phantom Dancer and pop out of Ambush you will have 2.500 attack speed
Mercury's Treads -good late game boots, gives you magic resist which you need against casters
Banshee's Veil -very good defensive item, especially against casters, also provides health and mana :D
Pros/Cons
Pros: One of the best AD carry's in the game
Good runner with Ambush
Very good last hitter and kser xD
Cons: Very squishy
Needs someone to start a fight for him
The most focused target in a teamfights
Creeping/Jungling
Twitch isn't good jungler cause he has too low hp but after lvl 11 you should grab Blessing of the Lizzard Elder WHENEVER YOU CAN!!!!
Farming
About farming, if you play solo lane you will have to get 95% minion kills, that's right 9/10 minons, but if you play duo lane you should get 6/10 minions... Just autoattack them once and when they are low hp use your Expunge (if you didnt understand let me explain it beter:autoattack 6 minons and when most of them are low hp use Expunge )
The Champions You Should Avoid (NEW)
This is my new chapter in which I will explain some champions that can easily pwn you in a matter of 3 seconds...
Olaf - Your worst nightmare,he is tanky DPS and has too much HP and damage output for you, it doesn't matter if you know that you already play vs him, even if you do take exhaust it's no use, his ulti is like cleanse...
Just one more important tip: (everything red is important) if you see Olaf on half health just run,because his passive; 
Berserker Rage , he is more dangerous half health than full, you can only get him untill lvl 6 when he is not so durable...
Shen - he just has too much hp for you, and if you try to run, he will taunt you with 
Shadow Dash so try to avoid him as much as you can...
Rammus - same story as Shen but only Rammus can kill you faster...
one tip: when in a teamfight vs Rammus you should stay stealthed until he uses his QUER combo, when he does, pop out of Ambush and from safe distance try to damage him as much as you can
Annie - ALERT!!!!! Annie can kill you in 2 secs (verified) if she has her 
Pyromania ready then you are ****, she will stun you with 
Summon: Tibbers , then will use 
Incinerate and will spam 
Disintegrate ... there's no tips for Annie, you just can't kill her 1 vs 1 unless you are feeded
Sion - too much damage + 
Cryptic Gaze = pwned
Jarvan IV - you can try to fight him but when you notice that you cant kill him you would try to escape with Ambush , which won't work!!!! here are 2 resons why... When you Ambush yourself he will throw 
Demacian Standard and ixtend his 
Dragon Strike into it and you will be visible again after you will be visible he will use 
Cataclysm on you and you will be pwned
Leona - too much stuns and CC's and also hp = dead
Karthus - Karthus is easily slain if you know how to position yourself against him and if you don't I'll explain it to you: When you know that you are going in a fight versus him, DON'T GO STEALTHED (cause you will maybe need it to escape), he will ofc turn on his 
Defile and try to spam 
Lay Waste on you, to avoid so, you will need to turn on your Spray and Pray and attack him from safe distance, when he comes closer, 1 time attack him and move to the right,then again attack him once and move to the right,after that attack him twice and move to the left and etc... if you kill him, run as fast as you can and go in Wolf's Camp and return your hp with The Bloodthirster
Malphite & 
Cho'Gath - Malphite and Cho'Gath are very similar,both have 2 CC's and much hp, avoid them, if Cho'Gath proper adjusts 
Rupture you are dead, cause he will then silence you so you cant use Ambush autoattack you twice and then finish you with 
Feast ... Malphite will first slow you with 
Seismic Shard then will use 
Unstoppable Force , 
Ground Slam and finish you off with normal attacks
Mordekaiser - like Olaf he is your worst nighmare...has too much hp survivability and magic damage output for you, just dont try to go 1 vs 1 him never, you will just FAIL hardly... he will nuke you with 
Siphon of Destruction , put his 
Creeping Death on him, throw 
Children of the Grave on you and finish you with 
Mace of Spades and to be harder, his passive: 
Iron Man grants him shield which when its maxed can protect him from your maximized Expunge with 6 stacks of Deadly Venom ...
CONCLUSION: AVOID Mordekaiser AS MUCH AS YOU CAN!!!!!!!!
Summary
This is the guide how I play Twitch,the plague rat or how I like to call him: "The smelly nightmare"...
Hope you all liked it and plz comment and rate!!!
Special thanks to ShadowNet for the picture from the Introduction ^^
Build Guide
Discussion (20)
Greater Seal of Evasion -no explanation, sometimes dodge saves you from AD's
Greater Glyph of Magic Resist - Magic Resistance is also one of the thungs you need early game
Greater Quintessence of Health - Very good early game, you're not as squishy as normal
Greater Mark of Critical Chance
Exhaust for heavy AD team or 
Cleanse for heavy caster team...
