Not Updated For Current Season
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
With this build it is important to have a good team with you since twitch is pretty squishy. It is harder to solo gank early game with this build so you wanna have someone with you who can keep the enemies attention and take some damage until you can get into a suitable position to keep them from escaping you while you eat their souls. Mid game is when you start to make the enemy fear you not being seen on the map as you will be ganking the other lanes with your friends. after a few ganks the enemy WILL start to be more careful and stay closer to turrets, the smarter ones will buy wards or an Oracles elixer to try to keep you from eating their souls. Now there will be a time when you run into a gank meant just for your soul eating rat face, if there is only 2-3 of them exhaust the strongest physical enemy, pop your Spray and Pray, heal when you are almost dead, pop expunge and watch as their limp bodies fall to the ground. I have done really well with this build and average 20-40 kills per match. sorry this isn't in greater detail, I will try to update it later if possible