Twitch Build Guide by
Not Updated For Current Season
So I've been playing Twitch since open beta and I've seen so many players play him in a way where his attack speed is not maximized. Also, twitch should not be played bot lane, because yes, he will lose against other AD carries. Twitch should be played top. If you don't believe me, try it for yourself. Use this guide to play as Twitch Solo Top Lane and you'll be the most useful character on your team. The fact you don't build sustain is compensated with the amount of lifesteal you get with a single basic attack. Your ult will destroy the enemy team and it's hard to have a negative score if played right. The key is to play rather passive early game, farming as much as you can. Most top lane champions are melee, meaning you can harass them with your basic attacks as long as your stay out of range of their spells. Farm a lot and harass your opponent and you'll have no troubles carrying your team.
Take armor pen marks to do extra damage early game, magic/level seals for sustain, armor/level glyphs for sustain, and health quints. for sustain both early and late game.
24/6/0 making sure you grab all attack masteries as to hurt your opponents while keeping a bit of sustain.
Take a point early in ambush in case of any early ganks. This is your best escape tool (along with flash). Max expunge, then max stealth to stay invisible for longer.