Not Updated For Current Season
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
Okay this is my first guide, so I will try my best. Vayne is the newest champ. I will be updating and adding pictures and screen shots when I test items, or get more time. She has very high scaled damage and items that maximize this make her even stronger. This guide will help give you a balanced build and does high damage. I perfer to use her in mid to lvl faster and get your items faster for 1v1 kills quick. I just make sure to also ward the mid to help me and my team.
She is also a good laner. She is very good in team fights. She has a stun and plus she can knock enemies away from team mates and save them. She is also a very good chaser and has great escape skills. Her attack speed is very good with this build. She can get fast kills and take out lots of hp with build, even on tanks quick.
Please try this build out and let me know what you think. If you use my build please vote and comment to any things I could change or recommend.
Greater Mark of Desolation
Greater Quintessence of Desolation
depending if you go Berserker's Greaves or Ionian Boots of Lucidity
The runes I chose are for high damage early-mid-late and to balance Vayne. The Greater Mark of Desolation and Greater Quintessence of Desolation armor pen will help take on anyone. The flat Greater Glyph of Magic Resist magic resist will help if you have to go against any mage type, but you can switch these out for Greater Glyph of Cooldown Reduction flat cooldown or Greater Glyph of Scaling Cooldown Reduction lvl cooldown runes if you want to get Berserker's Greaves. The attack speed of course you want to shoot fast.
The CORE ITEMS FOR Vayne
I always get these items in usually this order.
Situational defense item
The items well you want damage that scales, since she has Silver Bolts that do hp damage in the third hit, which isn't hard to get. I get a sheen soon as possible to help increase the damage of silver bolts on third hits. The trinity force well that is for slowing them down some and increasing your base.
Max Tumble first
Max Condemn second
Max Silver bolts last, Put 1 point at lvl 3 or 4
point at 6,11,16
It is nice she does more damage when they hit a wall and then they are stunned with her Condemn skill.
You can tumble foward and backwards for quick escapes.
You can always save your condemn shot to push them away from you.
= stealth+movement speed
The skill sequence will help you be able to farm easy since you can get closer or distance easy with tumble.
Keep your range as much as possible till you can get them out of position and use your Condemn to stun them against the wall. She a good harasser to always harass much as possible. You can even keep them from getting exp by staying above their minons.
Thanks to my friends that looked over and gave me there comments to improve this guide.