Anti top hyper carry.
Threats to Vayne with this build
|Nasus||Easiest match up you have ever seen 0% chance of winning lane|
I am not here to hold your hand. I gave you the general build, information about runes, and a wide spectrum of champions to compare Vayne too. so much so that, if you were to see a fizz go top, rather then Mid or Jungle you would be able to understand that fizz is a similar to Irelia in the way that he won't have problems catching you then nuking you.
P.S. try the build out, have some fun, I know I will. Master this champion and its an easy climb to gold.