Not Updated For Current Season
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
Threats to Vayne with this build
|Ezreal||Simple, Dodge his q's with your q, then attack him. If fighting, get up close to his face so if he channels ultimat just tumble behind him. Same for his q's if you can time it right.|
|Lucian||Q out of his q, But he has a scary ult if he hits you with it all. Tumble out of his ult or E him away to prevent this.|