This is my build guide for vayne, its pretty basic atm but it will be added to along the line with improvements as they become apparent.

Most people looking at this guide might not get it to start with, please try it in-game before you comment or rate on how good it is. Theyre are 2 seperate builds one for speed and one for pure damage. The speed build may look shakey but the incredible attack speed combined with silver bolts on every third and bonus magic on ever forth attack from Sword of the Divine adds up to huge damage over a very small amount of time. The life steal gained from such fast attacks really helps with survivalability (if thats a word?) and means that she can even tower dive with suprising success tho she has very low hp.

The second build for damage is for people who love to tumble like theyre life depends on it, the high AD greatly increases the bonus damage on the next attack after tumble, and seeing as level 5 tumble has a base cooldown of about 1.7 seconds its fairly easy to spam for the bonus damage.

Even though the builds are very different they have one key similarity, movement speed. I believe it is key to catching enemies unaware, if with the help of boots, ultimate and ghost your speed exceeds 600 very little will stop you from chasing down your opponent and finishing the job. Saying that, if you want to be what I call a "seeker destroyer" and chase your opponents down you may want to buy Cloak and Daggers, the tenacity will help if peoples escape method is to stun you. Cloak and Daggers also gives you attack speed and crit chance, very useful when it comes to combat with vayne.

Few things ive figured out from personal use on vayne is that condemn isn't something you want to overly wait to use till they are near terrain for bonus dmg and also isn't a skill your really want to depend on for dmg.

I think they key advantage of condemn is to use it at the very START of a fight, ambush or suprise your oppoent by tumbling behind them and immediately using condemn to knock they further from towers/base/allies who can assist them. With high attack speed the time it takes them to recover this ground is more than enough time to land silver bolts 3rd stack for 8% true dmg and to start the stack again.

Another tip, Vayne speed build may have lifesteal to help her survive fights but still remeber her health is VERY low, 2v1s she will still struggle unless 1 target is squishy and can be eliminated quickly. Bidding your time till the squishy champions strays too far from the pack and then quickly eliminating may be the best course of action tumble with or without ulti combined with condemn can accomplish this quickly.