Vayne The 1v5ing Godess
Not Updated For Current Season
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
I start Q, then go e or w, depending on if my support is agressive. If they are an aggressive support like Thresh, then I recommend going e 2nd. If you are against a lane with a lot of poke and skillshots then i recommend maxing q. Then max w after q is level 4. Then max your condemn. And of course, upgrade your Final Hour at all levels where it can be upgraded.