In this guide I will show you two of my vayne builds:
Vayne, the Tank-Destroyer (Build 1) and Vayne, the Burst-Carry (Build 2)
As usual this builds are just my way to play vayne and are not used to be "the best hardcore op imba have to use vayne build, that makes you carry every game by following my orders, if you don't, blame yourself because you didn't get that lasthit on 12:37" !!! I hope you can atleast understand why I build her this way and maybe give me a review of how it worked for you. Feel free to comment and vote !!!

I use the same runes for both builds, because the difference between this builds consists of the playstyle and the itembuild. I use pretty basic runes for her just as for my other carry's on botlane because im not one of those 2k elo players that mix a certain amount of ArPen and AD to reach maximum DPS. I'm just using 2 pages for botlane: Support and AD !!!
ArPen Marks: obvious
Flat Armor Seals: some extra tankyness for early hit trades
AS Glyphs: better lasthitting when 2 or more minions are low
Flat AD Quints: better lasthitting