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This guide has not yet been updated for the current season. Please keep this in mind while reading. You can see the most recently updated guides on the browse guides page.
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
This build showes a great build for vayne the nighthunter. With this build you will kill everything... I prefer to go for HUGE Attackspeed in early and late game, but for hardcore dmg as well.