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want to harass constantly with tumble. It is an absolutely great move with a low cool down and strong damage. I get one in condemn early for the stun, in case your opponent goes against a wall, besides that tumble and silver bolts take presidence.
Vayne is a great hero for running heros down, it is what you excel at. If a team fight breaks out stay back and try and snipe heros that are squishy. However, you cannot take much damage so it is key that you dont just run in and get bursted down before you can do anything. Midding is great for her because if you can take out the middle hero, she is great for ganking sides with her ultimate. I also, recommend using your ultimate as much as possible. Also, make sure that you are never in front of your whole team in late game, I have been killed numerous times due to running into bushes blindly.
For items, sheen is great, especially earlier game because it makes her tumble do even more damage, and tumble has a low cooldown, so it can deal great damage. I then head into bloodthirster for life steal to keep me alive and the damage, followed by phantom dancer which makes me attack faster, causing silver bolts to proc more often. On top of that, bloodrazer causes each hit to do 4% per hit more damage on tiop of your attack, and then 8% when silver bolts is maxed out, so in four hits you do about 20% not including the damage you already deal in physical damage, of course you have to account for physical and magic resistance (bloodrazer), but either way your dealing massive amounts of damage.
For spells, I use flash, because it is an absolutely awesome for chasing down people, or getting away in those close situations.
Then exhaust becasue it can help slow down your target you are chasing, and more importantly if you get into a fight against a melee who is up close, you can pop this and they do barely any damage and cant attack as fast, giving you the advantage, so while they think they are gonna win, you can quickly turn the tide with the amount of damage you do.
Before level 12 though, I would use heal to make yourself more durable, or ghost to get out of sticky situations like flash and chasing down (this is probably the most ideal).
You could get ignite, but most of the time you can just chase down people or deal so much damage that ignite is not as useful.
If you really want to be a pusher, which she is excellent at, especially in the end game, I would use teleport.