I'll +1 this, but I do feel that dropping PD for a black clever or armor pen would do better. Overall its something that I feel work really well on Vayne. Have to give it a try.

im not sure since the critical is weak and removing ad and adding attck speed doesnt mean that u get the same power : IF u have 1 ad and 1/sec as to double you damage u should either buy 1 ad or make the 1/sec to 2/sec by byuing 100% as which means that u nedd balanced ad and as

If you go with madred, you should max silver bolts first.

215% additional attack speed is somewhat excessive considering that atkspd caps at 2.5atks/sec. You could probably slacken a bit on the atkspd and put more into armorpen or even flat out damage.PD should probbly be replaced with a black cleaver.

I like the Madred's, Wits End and Tri Force, but I think that the PD would be better replaced by an armor or even magic pen item (because of your magic damage from Wits and Madred's) so that you won't be hard countered by tanks stacking resists.

So basically... They nerf the base damage of her skills, and you make a guide explaining that you don't need that much AD? AD would be what makes up for the loss in base damage. Even if the AD ratio has been nerfed as well.

Your health and mana per 5 sec both are 2 per 5 sec. Persevereance gives you 4%. 4% of 2 is 0.08. You got a bonus of 0.08hpORmp/5sec. Thats pretty much useless. Good hands is better, taking off 7 seconds of your death timer.

Most ADs take ghost. If played safe enough, there is no need to flash at all.

Besides that its a relatively decent guide :)

Hope my comments help!